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Search results 1 to 100 out of 455 for Bcl2l11

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Category: Publication
Type Details Score
Publication
First Author: Li J
Year: 2020
Journal: Aging (Albany NY)
Title: MicroRNA-338-5p alleviates neuronal apoptosis via directly targeting BCL2L11 in APP/PS1 mice.
Volume: 12
Issue: 20
Pages: 20728-20742
Publication
First Author: Kotzin JJ
Year: 2016
Journal: Nature
Title: The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.
Volume: 537
Issue: 7619
Pages: 239-243
Publication
First Author: Cai Z
Year: 2020
Journal: Cell Rep
Title: Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.
Volume: 31
Issue: 12
Pages: 107816
Publication
First Author: Melum E
Year: 2011
Journal: Nat Genet
Title: Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
Volume: 43
Issue: 1
Pages: 17-9
Publication
First Author: Leidy-Davis T
Year: 2018
Journal: Sci Rep
Title: Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches.
Volume: 8
Issue: 1
Pages: 15028
Publication
First Author: Goh W
Year: 2020
Journal: Cell Rep
Title: Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance.
Volume: 33
Issue: 3
Pages: 108285
Publication  
First Author: Delconte RB
Year: 2020
Journal: Front Immunol
Title: NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.
Volume: 11
Pages: 75
Publication
First Author: Spruce T
Year: 2010
Journal: Dev Cell
Title: An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo.
Volume: 19
Issue: 2
Pages: 207-19
Publication
First Author: Chuang PY
Year: 2011
Journal: PLoS One
Title: Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus.
Volume: 6
Issue: 8
Pages: e23566
Publication  
First Author: Phua YL
Year: 2015
Journal: Physiol Rep
Title: Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.
Volume: 3
Issue: 10
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Liston A
Year: 2004
Journal: Immunity
Title: Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.
Volume: 21
Issue: 6
Pages: 817-30
Publication
First Author: He S
Year: 2012
Journal: Blood
Title: Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells.
Volume: 119
Issue: 5
Pages: 1274-82
Publication
First Author: Tsukamoto H
Year: 2010
Journal: J Immunol
Title: Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects.
Volume: 185
Issue: 8
Pages: 4535-44
Publication
First Author: Tsukamoto H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects.
Volume: 106
Issue: 43
Pages: 18333-8
Publication
First Author: Enders A
Year: 2003
Journal: J Exp Med
Title: Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells.
Volume: 198
Issue: 7
Pages: 1119-26
Publication
First Author: Burrows N
Year: 2020
Journal: Nat Immunol
Title: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.
Volume: 21
Issue: 11
Pages: 1408-1420
Publication  
First Author: Marchingo JM
Year: 2016
Journal: Nat Commun
Title: T-cell stimuli independently sum to regulate an inherited clonal division fate.
Volume: 7
Pages: 13540
Publication
First Author: Suen AY
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens.
Volume: 109
Issue: 3
Pages: 893-8
Publication
First Author: Wang S
Year: 2017
Journal: PLoS One
Title: Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature.
Volume: 12
Issue: 5
Pages: e0178198
Publication
First Author: Miller AV
Year: 2013
Journal: PLoS One
Title: Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.
Volume: 8
Issue: 4
Pages: e60685
Publication
First Author: Overall SA
Year: 2016
Journal: Int Immunol
Title: Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture.
Volume: 28
Issue: 10
Pages: 513-518
Publication
First Author: Jay DC
Year: 2013
Journal: PLoS One
Title: Bim mediates the elimination of functionally unfit Th1 responders from the memory pool.
Volume: 8
Issue: 6
Pages: e67363
Publication
First Author: Goodyear CS
Year: 2007
Journal: J Immunol
Title: Cutting Edge: Bim is required for superantigen-mediated B cell death.
Volume: 178
Issue: 5
Pages: 2636-40
Publication
First Author: Clybouw C
Year: 2012
Journal: Cell Death Differ
Title: Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.
Volume: 19
Issue: 6
Pages: 1060-8
Publication
First Author: Bouillet P
Year: 1999
Journal: Science
Title: Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
Volume: 286
Issue: 5445
Pages: 1735-8
Publication
First Author: Fox AC
Year: 2011
Journal: J Immunol
Title: Prevention of lymphocyte apoptosis in septic mice with cancer increases mortality.
Volume: 187
Issue: 4
Pages: 1950-6
Publication
First Author: Pierce J
Year: 2006
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia.
Volume: 291
Issue: 5
Pages: L862-70
Publication
First Author: Hettich M
Year: 2016
Journal: Cancer Res
Title: Checkpoint Antibodies but not T Cell-Recruiting Diabodies Effectively Synergize with TIL-Inducing γ-Irradiation.
Volume: 76
Issue: 16
Pages: 4673-83
Publication
First Author: Oliver PM
Year: 2006
Journal: J Exp Med
Title: Loss of the proapoptotic protein, Bim, breaks B cell anergy.
Volume: 203
Issue: 3
Pages: 731-41
Publication
First Author: Hu Q
Year: 2009
Journal: J Immunol
Title: Bim-mediated apoptosis is not necessary for thymic negative selection to ubiquitous self-antigens.
Volume: 183
Issue: 12
Pages: 7761-7
Publication
First Author: Alfredsson J
Year: 2005
Journal: Cell Death Differ
Title: Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation.
Volume: 12
Issue: 2
Pages: 136-44
Publication
First Author: Wali JA
Year: 2018
Journal: Cell Death Differ
Title: Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.
Volume: 25
Issue: 1
Pages: 217-225
Publication
First Author: Ludwinski MW
Year: 2009
Journal: J Clin Invest
Title: Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice.
Volume: 119
Issue: 6
Pages: 1706-13
Publication
First Author: Andina N
Year: 2009
Journal: Cell Death Differ
Title: Induction of Bim limits cytokine-mediated prolonged survival of neutrophils.
Volume: 16
Issue: 9
Pages: 1248-55
Publication
First Author: Mingueneau M
Year: 2013
Journal: Nat Immunol
Title: The transcriptional landscape of αβ T cell differentiation.
Volume: 14
Issue: 6
Pages: 619-32
Publication
First Author: Richter-Larrea JA
Year: 2010
Journal: Blood
Title: Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma.
Volume: 116
Issue: 14
Pages: 2531-42
Publication
First Author: Roberts SL
Year: 2020
Journal: Hum Mol Genet
Title: Bim contributes to the progression of Huntington's disease-associated phenotypes.
Volume: 29
Issue: 2
Pages: 216-227
Publication
First Author: Reckling S
Year: 2008
Journal: Infect Immun
Title: Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity.
Volume: 76
Issue: 3
Pages: 1179-85
Publication
First Author: Murphy BM
Year: 2010
Journal: Cell Death Differ
Title: Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.
Volume: 17
Issue: 3
Pages: 459-68
Publication
First Author: Williams EL
Year: 2012
Journal: Eur J Immunol
Title: Development and characterisation of monoclonal antibodies specific for the murine inhibitory FcγRIIB (CD32B).
Volume: 42
Issue: 8
Pages: 2109-20
Publication
First Author: Cippà PE
Year: 2013
Journal: Blood
Title: Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice.
Volume: 122
Issue: 9
Pages: 1669-77
Publication
First Author: Bauer A
Year: 2007
Journal: Cell Death Differ
Title: Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes.
Volume: 14
Issue: 9
Pages: 1714-6
Publication
First Author: Wang S
Year: 2011
Journal: Dev Biol
Title: Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia.
Volume: 349
Issue: 2
Pages: 296-309
Publication
First Author: Wojciechowski S
Year: 2006
Journal: Eur J Immunol
Title: Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory.
Volume: 36
Issue: 7
Pages: 1694-706
Publication
First Author: Doonan F
Year: 2007
Journal: J Neurosci
Title: Bim expression indicates the pathway to retinal cell death in development and degeneration.
Volume: 27
Issue: 40
Pages: 10887-94
Publication
First Author: Leucht K
Year: 2013
Journal: Clin Exp Immunol
Title: Impaired removal of Vβ8(+) lymphocytes aggravates colitis in mice deficient for B cell lymphoma-2-interacting mediator of cell death (Bim).
Volume: 173
Issue: 3
Pages: 493-501
Publication
First Author: Lauer C
Year: 2012
Journal: J Immunol
Title: The proapoptotic Bcl-2 family member Bim plays a central role during the development of virus-induced hepatitis.
Volume: 188
Issue: 2
Pages: 916-22
Publication
First Author: Litwak SA
Year: 2017
Journal: Diabetes
Title: JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.
Volume: 66
Issue: 12
Pages: 2973-2986
Publication
First Author: Holz LE
Year: 2008
Journal: Gastroenterology
Title: Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death.
Volume: 135
Issue: 3
Pages: 989-97
Publication
First Author: Desbien AL
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim.
Volume: 106
Issue: 14
Pages: 5663-8
Publication
First Author: Bouillet P
Year: 2001
Journal: Mamm Genome
Title: Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim.
Volume: 12
Issue: 2
Pages: 163-8
Publication
First Author: Seward RJ
Year: 2003
Journal: Mol Immunol
Title: Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis.
Volume: 39
Issue: 16
Pages: 983-93
Publication
First Author: Wang P
Year: 2004
Journal: J Biol Chem
Title: Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins.
Volume: 279
Issue: 40
Pages: 41280-5
Publication
First Author: Kirschnek S
Year: 2005
Journal: J Immunol
Title: Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim.
Volume: 174
Issue: 2
Pages: 671-9
Publication
First Author: Bunin A
Year: 2005
Journal: J Immunol
Title: Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes.
Volume: 175
Issue: 3
Pages: 1532-9
Publication
First Author: Hamrouni A
Year: 2007
Journal: Eur J Immunol
Title: Impact of cellular lifespan on the T cell receptor repertoire.
Volume: 37
Issue: 7
Pages: 1978-85
Publication
First Author: Barron L
Year: 2008
Journal: J Immunol
Title: Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance.
Volume: 180
Issue: 5
Pages: 2762-6
Publication
First Author: Chen S
Year: 2009
Journal: Mol Cell Biol
Title: Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.
Volume: 29
Issue: 23
Pages: 6149-69
Publication
First Author: Gao Y
Year: 2012
Journal: Int Immunol
Title: Bim regulates B-cell receptor-mediated apoptosis in the presence of CD40 signaling in CD40-pre-activated splenic B cells differentiating into plasma cells.
Volume: 24
Issue: 5
Pages: 283-92
Publication
First Author: Iyoda T
Year: 2014
Journal: J Immunol
Title: A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection.
Volume: 192
Issue: 9
Pages: 4254-62
Publication
First Author: Tsai F
Year: 2017
Journal: J Exp Med
Title: Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
Volume: 214
Issue: 12
Pages: 3753-3773
Publication
First Author: Falero-Perez J
Year: 2020
Journal: PLoS One
Title: Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells.
Volume: 15
Issue: 5
Pages: e0232779
Publication
First Author: Zhang X
Year: 2019
Journal: J Cell Mol Med
Title: LncRNA SNHG6 functions as a ceRNA to regulate neuronal cell apoptosis by modulating miR-181c-5p/BIM signalling in ischaemic stroke.
Volume: 23
Issue: 9
Pages: 6120-6130
Publication
First Author: Li KP
Year: 2020
Journal: Cell Death Differ
Title: T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate.
Volume: 27
Issue: 4
Pages: 1214-1224
Publication  
First Author: Liu R
Year: 2018
Journal: Front Immunol
Title: Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Volume: 9
Pages: 592
Publication
First Author: von Rossum A
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Bim regulates alloimmune-mediated vascular injury through effects on T-cell activation and death.
Volume: 34
Issue: 6
Pages: 1290-7
Publication
First Author: Weber A
Year: 2016
Journal: EMBO Rep
Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.
Volume: 17
Issue: 5
Pages: 724-38
Publication
First Author: Liu X
Year: 2003
Journal: Immunity
Title: The structure of a Bcl-xL/Bim fragment complex: implications for Bim function.
Volume: 19
Issue: 3
Pages: 341-52
Publication
First Author: Thompson S
Year: 2011
Journal: J Biol Chem
Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
Volume: 286
Issue: 22
Pages: 19331-9
Publication
First Author: Coultas L
Year: 2007
Journal: J Cell Sci
Title: Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.
Volume: 120
Issue: Pt 12
Pages: 2044-52
Publication
First Author: Akiyama T
Year: 2003
Journal: EMBO J
Title: Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.
Volume: 22
Issue: 24
Pages: 6653-64
Publication
First Author: Salmanidis M
Year: 2013
Journal: Cell Death Differ
Title: Hoxb8 regulates expression of microRNAs to control cell death and differentiation.
Volume: 20
Issue: 10
Pages: 1370-80
Publication
First Author: Masson F
Year: 2011
Journal: J Immunol
Title: Bid and Bim collaborate during induction of T cell death in persistent infection.
Volume: 186
Issue: 7
Pages: 4059-66
Publication
First Author: Bradfute SB
Year: 2010
Journal: J Immunol
Title: Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.
Volume: 184
Issue: 1
Pages: 327-35
Publication
First Author: Hübner A
Year: 2010
Journal: Mol Cell Biol
Title: Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.
Volume: 30
Issue: 1
Pages: 98-105
Publication
First Author: Vremec D
Year: 2015
Journal: Mol Immunol
Title: Maintaining dendritic cell viability in culture.
Volume: 63
Issue: 2
Pages: 264-7
Publication
First Author: Pellegrini M
Year: 2004
Journal: J Exp Med
Title: Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice.
Volume: 200
Issue: 9
Pages: 1189-95
Publication
First Author: Maréchal Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.
Volume: 104
Issue: 35
Pages: 13978-83
Publication
First Author: Marchingo JM
Year: 2014
Journal: Science
Title: T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion.
Volume: 346
Issue: 6213
Pages: 1123-7
Publication
First Author: Sabbagh L
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival.
Volume: 103
Issue: 49
Pages: 18703-8
Publication
First Author: Bean GR
Year: 2013
Journal: Sci Signal
Title: PUMA and BIM are required for oncogene inactivation-induced apoptosis.
Volume: 6
Issue: 268
Pages: ra20
Publication
First Author: Erlacher M
Year: 2006
Journal: J Exp Med
Title: Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction.
Volume: 203
Issue: 13
Pages: 2939-51
Publication
First Author: Merino D
Year: 2015
Journal: Oncogene
Title: Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2.
Volume: 34
Issue: 30
Pages: 3926-34
Publication
First Author: Labi V
Year: 2014
Journal: Blood
Title: Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.
Volume: 123
Issue: 17
Pages: 2652-62
Publication
First Author: Nordigården A
Year: 2009
Journal: Blood
Title: BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Volume: 113
Issue: 10
Pages: 2302-11
Publication
First Author: Tsuchiya T
Year: 2011
Journal: Eur J Neurosci
Title: Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.
Volume: 33
Issue: 3
Pages: 401-8
Publication
First Author: Chino T
Year: 2009
Journal: J Leukoc Biol
Title: Regulation of dendritic cell survival and cytokine production by osteoprotegerin.
Volume: 86
Issue: 4
Pages: 933-40
Publication
First Author: Maeda T
Year: 2009
Journal: Dev Cell
Title: LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.
Volume: 17
Issue: 4
Pages: 527-40
Publication
First Author: Barone MC
Year: 2008
Journal: J Neurochem
Title: Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.
Volume: 106
Issue: 2
Pages: 734-45
Publication
First Author: Putcha GV
Year: 2001
Journal: Neuron
Title: Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis.
Volume: 29
Issue: 3
Pages: 615-28
Publication
First Author: Ramos SJ
Year: 2008
Journal: J Immunol
Title: Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.
Volume: 181
Issue: 11
Pages: 7606-16
Publication
First Author: Bouillet P
Year: 2002
Journal: Nature
Title: BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes.
Volume: 415
Issue: 6874
Pages: 922-6
Publication
First Author: Delbridge AR
Year: 2015
Journal: Oncogene
Title: Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis.
Volume: 34
Issue: 14
Pages: 1872-6
Publication
First Author: Schoeler K
Year: 2019
Journal: Cell Death Differ
Title: CHK1 dosage in germinal center B cells controls humoral immunity.
Volume: 26
Issue: 12
Pages: 2551-2567
Publication
First Author: Craxton A
Year: 2005
Journal: J Exp Med
Title: BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway.
Volume: 202
Issue: 10
Pages: 1363-74
Publication
First Author: Oliver PM
Year: 2004
Journal: J Exp Med
Title: Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7.
Volume: 200
Issue: 9
Pages: 1179-87
Publication
First Author: Abutin RM
Year: 2009
Journal: Exp Hematol
Title: Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells.
Volume: 37
Issue: 2
Pages: 151-8
Publication
First Author: Katz SG
Year: 2014
Journal: Blood
Title: Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells.
Volume: 123
Issue: 6
Pages: 884-93
Publication
First Author: Akhtar RS
Year: 2008
Journal: J Histochem Cytochem
Title: Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice.
Volume: 56
Issue: 10
Pages: 921-7