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Search results 101 to 200 out of 272 for Gsr

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5298945
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2772126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5542932
Age: embryonic day 17.5
Image: GUDMAP:15696
Specimen Label: GUDMAP:15696
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3584847
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3585540
Age: embryonic day 12.0
Image: E12
Note: Expression was detected in a subset of cells in the outer neuroblastic layer.
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3584847
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3585540
Age: embryonic day 14.0
Image: E14
Note: Expression was detected in a subset of cells in the outer neuroblastic layer.
Specimen Label: E14
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4428838
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825254
Age: embryonic day 14.5
Image: euxassay_015904_09
Specimen Label: euxassay_015904_09
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4428838
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825254
Age: embryonic day 14.5
Image: euxassay_015904_10
Specimen Label: euxassay_015904_10
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4428838
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825254
Age: embryonic day 14.5
Image: euxassay_015904_11
Specimen Label: euxassay_015904_11
Detected: true
Specimen Num: 8
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Publication
9268726 | J:42358
First Author: Tamura T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Gene structure for mouse glutathione reductase, including a putative mitochondrial targeting signal.
Volume: 237
Issue: 2
Pages: 419-22
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Publication
31097586 | J:276547
First Author: McLoughlin MR
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Volume: 116
Issue: 23
Pages: 11408-11417
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Publication
6683708 | J:7133
First Author: Cox DR
Year: 1983
Journal: Hum Genet
Title: The metallothionein-I gene maps to mouse chromosome 8: implications for human Menkes' disease.
Volume: 64
Issue: 1
Pages: 61-4
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Publication
2413215 | J:8037
First Author: Müller G
Year: 1985
Journal: J Mol Biol
Title: Isolation, characterization and chromosomal mapping of the mouse tyrosine aminotransferase gene.
Volume: 184
Issue: 3
Pages: 367-73
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Publication
16244648 | J:103812
First Author: Hovatta I
Year: 2005
Journal: Nature
Title: Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.
Volume: 438
Issue: 7068
Pages: 662-6
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Publication
7576184 | J:29976
First Author: Lange R
Year: 1995
Journal: DNA Cell Biol
Title: Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains.
Volume: 14
Issue: 11
Pages: 971-81
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Publication
17363688 | J:135086
First Author: Qiao M
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice.
Volume: 27
Issue: 6
Pages: 1375-82
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Publication
8417789 | J:35956
First Author: Merkle S
Year: 1993
Journal: Blood
Title: Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease.
Volume: 81
Issue: 1
Pages: 206-13
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Publication
1694015 | J:10562
First Author: MacLeod CL
Year: 1990
Journal: Mol Cell Biol
Title: Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor.
Volume: 10
Issue: 7
Pages: 3663-74
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Publication
30198844 | J:269762
   
First Author: Lian G
Year: 2018
Journal: Elife
Title: Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.
Volume: 7
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Publication
25790857 | J:221873
 
First Author: Eriksson S
Year: 2015
Journal: Nat Commun
Title: Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.
Volume: 6
Pages: 6479
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Publication
1973375 | J:10614
First Author: McBride OW
Year: 1990
Journal: Cytogenet Cell Genet
Title: Mapping of the gene for DNA polymerase beta to mouse chromosome 8.
Volume: 53
Issue: 2-3
Pages: 108-11
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Publication
- | J:39060
     
First Author: Chang B
Year: 1998
Journal: MGI Direct Data Submission
Title: Improved genetic map for the mnd gene, using the retinal degeneration aspect of the phenotype
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Publication
33254076 | J:313517
 
First Author: Robbins ME
Year: 2021
Journal: Redox Biol
Title: Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice.
Volume: 38
Pages: 101797
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Publication
- | J:13713
 
First Author: Frels W
Year: 1977
Journal: Mouse News Lett
Title: Linkage of glutathione reductase (Gr).
Volume: 56
Pages: 58
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Publication
2139228 | J:10432
First Author: White RA
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin.
Volume: 87
Issue: 8
Pages: 3117-21
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Publication
1180875 | J:5572
First Author: Nichols EA
Year: 1975
Journal: Biochem Genet
Title: Polymorphism and linkage of glutathione reductase in Mus musculus.
Volume: 13
Issue: 5-6
Pages: 323-9
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Publication
2328987 | J:10436
First Author: Danciger M
Year: 1990
Journal: Genomics
Title: The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8.
Volume: 6
Issue: 3
Pages: 428-35
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Publication
2563260 | J:9560
First Author: Kirchgessner TG
Year: 1989
Journal: J Biol Chem
Title: Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression.
Volume: 264
Issue: 3
Pages: 1473-82
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Publication
7941361 | J:20841
First Author: Lyu MS
Year: 1994
Journal: Virology
Title: Genetic mapping of the amphotropic murine leukemia virus receptor on mouse chromosome 8.
Volume: 204
Issue: 2
Pages: 868-9
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Publication
27998725 | J:240186
First Author: Wang R
Year: 2017
Journal: Am J Pathol
Title: cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.
Volume: 187
Issue: 2
Pages: 377-389
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Publication
21554947 | J:172598
First Author: Brewer AC
Year: 2011
Journal: Free Radic Biol Med
Title: Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.
Volume: 51
Issue: 1
Pages: 205-15
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Publication
10706738 | J:69083
First Author: Blankenhorn EP
Year: 2000
Journal: J Immunol
Title: Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints.
Volume: 164
Issue: 6
Pages: 3420-5
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Publication
1235912 | J:5817
First Author: Kozak C
Year: 1975
Journal: Somatic Cell Genet
Title: Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome.
Volume: 1
Issue: 4
Pages: 371-82
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Publication
204065 | J:5946
First Author: Kozak CA
Year: 1977
Journal: Somatic Cell Genet
Title: Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids.
Volume: 3
Issue: 2
Pages: 121-33
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Publication
6276492 | J:6689
First Author: Kozak CA
Year: 1982
Journal: J Exp Med
Title: Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains.
Volume: 155
Issue: 2
Pages: 524-34
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Publication
1981050 | J:10989
First Author: Nadeau JH
Year: 1990
Journal: Genomics
Title: Zinc finger protein gene complexes on mouse chromosomes 8 and 11.
Volume: 8
Issue: 3
Pages: 469-76
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Publication
198184 | J:5872
First Author: Francke U
Year: 1977
Journal: Cytogenet Cell Genet
Title: Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2.
Volume: 19
Issue: 2-3
Pages: 57-84
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Publication
25395457 | J:217594
First Author: Plosa EJ
Year: 2014
Journal: Development
Title: Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.
Volume: 141
Issue: 24
Pages: 4751-62
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Publication
7323947 | J:6674
First Author: Stallings RL
Year: 1981
Journal: Somatic Cell Genet
Title: Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7.
Volume: 7
Issue: 6
Pages: 683-98
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Publication
7873878 | J:21511
First Author: Kaushik N
Year: 1994
Journal: Mamm Genome
Title: Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.
Volume: 5
Issue: 11
Pages: 688-95
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Publication
4042679 | J:8016
 
First Author: Hilgers J
Year: 1985
Journal: Curr Top Microbiol Immunol
Title: A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.
Volume: 122
Pages: 31-7
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Publication
1686571 | J:11622
First Author: Moen CJ
Year: 1991
Journal: Mamm Genome
Title: The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.
Volume: 1
Issue: 4
Pages: 217-27
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Publication
8094303 | J:3881
First Author: Johnson KR
Year: 1993
Journal: Mamm Genome
Title: Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17.
Volume: 4
Issue: 2
Pages: 83-9
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Publication
8903730 | J:31555
First Author: Stassen AP
Year: 1996
Journal: Mamm Genome
Title: Genetic composition of the recombinant congenic strains.
Volume: 7
Issue: 1
Pages: 55-8
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Publication
38191655 | J:344186
First Author: Muñoz-Gallardo MDM
Year: 2024
Journal: Sci Rep
Title: miR-195b is required for proper cellular homeostasis in the elderly.
Volume: 14
Issue: 1
Pages: 810
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Publication
30938680 | J:274697
   
First Author: Celaya AM
Year: 2019
Journal: Elife
Title: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.
Volume: 8
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Publication
31220272 | J:277277
First Author: Zieman AG
Year: 2019
Journal: Hum Mol Genet
Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.
Volume: 28
Issue: 13
Pages: 2255-2270
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Publication
24029230 | J:202604
First Author: Nagamachi A
Year: 2013
Journal: Cancer Cell
Title: Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Volume: 24
Issue: 3
Pages: 305-17
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Publication
- | J:103485
     
First Author: Lexicon Genetics Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories
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Publication
27689697 | J:235644
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355
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Publication
19521566 | J:177549
First Author: Willnow T
Year: 2005
Journal: Organogenesis
Title: The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.
Volume: 2
Issue: 2
Pages: 42-7
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Publication
14651853 | J:86816
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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QTL
MGI:1932465 | Gusr
Type: QTL
Organism: mouse, laboratory
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Publication
3007037 | J:8227
First Author: Berman EJ
Year: 1986
Journal: Cytogenet Cell Genet
Title: Chromosomal mapping of enzyme loci in the domestic cat: GSR to C2, ADA and ITPA to A3, and LDHA-ACP2 to D1.
Volume: 41
Issue: 2
Pages: 114-20
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HT Experiment
GSE116485 | Effect of glutathione reductase (Gsr) deficiency on lung transcriptomics in embryonic mice and neonatal and adult mice exposed to hyperoxia.
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
20587944 | J:290491
First Author: Tashima I
Year: 2010
Journal: J Oral Sci
Title: Genetic study of gutter-shaped root (GSR) in AKXL RI mouse strains using QTL analysis.
Volume: 52
Issue: 2
Pages: 213-20
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Publication
10808271 | J:66472
First Author: Matsune K
Year: 2000
Journal: J Oral Sci
Title: Molecular genetic study of the gutter shaped root (GSR) on mouse chromosome 17.
Volume: 42
Issue: 1
Pages: 21-6
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Publication
28081255 | J:248069
First Author: Tabish AM
Year: 2017
Journal: PLoS One
Title: Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials.
Volume: 12
Issue: 1
Pages: e0169886
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Publication
20660283 | J:163618
First Author: Wu X
Year: 2010
Journal: J Nutr
Title: Dietary blueberries attenuate atherosclerosis in apolipoprotein E-deficient mice by upregulating antioxidant enzyme expression.
Volume: 140
Issue: 9
Pages: 1628-32
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Publication
10903450 | J:63630
First Author: Givogri MI
Year: 2000
Journal: Gene
Title: Identification of a novel silencer that regulates the myelin basic protein gene in neural cells.
Volume: 252
Issue: 1-2
Pages: 183-93
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Publication
6572613 | J:7013
First Author: Soulié J
Year: 1983
Journal: Hum Genet
Title: New gene assignments in the rabbit (Oryctolagus cuniculus). Comparison with other species.
Volume: 63
Issue: 1
Pages: 48-52
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Publication
19028565 | J:145186
First Author: Harvey CJ
Year: 2009
Journal: Free Radic Biol Med
Title: Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress.
Volume: 46
Issue: 4
Pages: 443-53
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Publication
1673462 | J:30989
First Author: Bhandari B
Year: 1991
Journal: J Biol Chem
Title: A functional promoter flanks an intronless glutamine synthetase gene.
Volume: 266
Issue: 12
Pages: 7784-92
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Protein
Q3UQD7
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
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Protein
Q6P556
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q8BLD2
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Publication
29373494 | -
 
First Author: Quick QA
Year: 2018
Journal: Int J Mol Sci
Title: Microtubule-Actin Crosslinking Factor 1 and Plakins as Therapeutic Drug Targets.
Volume: 19
Issue: 2
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Protein Domain
IPR043197 | Plakin
Type: Family
Description: Plakins are a family of seven cytoskeletal cross-linker proteins (microtubule-actin crosslinking factor 1 (MACF), bullous pemphigoid antigen (BPAG1) desmoplakin, envoplakin, periplakin, plectin, epiplakin) that network the major filaments of the cytoskeleton [].Plakins have been shown to play a diverse range of biological roles. MACF1 and BPAG1 perform cross-linking functions between actin and microtubules and have been shown to play roles in cell migration and microtubule organisation, while plectin cross-links intermediate filaments to microtubules [].Desmoplakin, envoplakin, periplakin and epiplakin are predominately involved in intermediate filament binding. They have been found to play a prominent role in the development of the cornified envelop, in the epidermis. Additional roles have been demonstrated for desmoplakin in myocardium morphogenesis, epidermis development, keratinocyte differentiation, and, along with MACF1, wound healing.Plakins have also been found to be involved in intracellular signalling cascades [].Plakin family members are built from combinations of the following modules: a calponin-type actin-binding domain (ABD); a plakin domain harbouring several α-helical bundles; a heptad-repeat-containing coiled-coil rod domain (CC-rod); a plakin-repeat domain (PRD) generally thought to have intermediate filament (IF)-binding properties, a function that in some cases requires an associated linker (L) subdomain; a spectrin repeat (SR)-containing rod domain; two EF-hand calcium-binding motifs; a Gas2-homology region called the GAR domain; and a domain containing GSR (Gly-Ser-Arg) repeats [].This family represents proteins found predominantly in metazoans.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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