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Search results 901 to 981 out of 981 for Braf

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Categories

Hits by Pathway

Hits by Strain

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Type Details Score
Allele
Tg(TG-BRAF*V600E)2Jaf | MGI:5524234
Name: transgene insertion 2, James A Fagin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5526854 | FVB/N-Tg(TG-BRAF*V600E)2Jaf
Attribute String: mutant strain, coisogenic, insertion
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Strain
MGI:5526853 | FVB/N-Tg(TG-BRAF*V600E)3Jaf
Attribute String: coisogenic, mutant strain, transgenic, insertion
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Genotype
Genotype
Symbol: Tg(TG-BRAF*V600E)2Jaf/?
Background: FVB/N-Tg(TG-BRAF*V600E)2Jaf
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(TG-BRAF*V600E)3Jaf/?
Background: FVB/N-Tg(TG-BRAF*V600E)3Jaf
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(tetO-BRAF*V600E)26Jaf/? Tg(TG-rtTA)30Jaf/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
27261482 | J:236808
First Author: VirĂ³s A
Year: 2016
Journal: Cancer Discov
Title: So You Can Teach Old Fibroblasts New Tricks.
Volume: 6
Issue: 6
Pages: 581-3
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Kras/Kras<+> Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Allele
Gt(ROSA)26Sor<tm2(RNAi:Braf)Rkuhn> | MGI:3785790
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ralf Kuhn
Allele Type: Targeted
Attribute String: Knockdown, RMCE-ready
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(GFAP-cre)#Gtm/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
23152448 | J:191207
First Author: Kaul A
Year: 2012
Journal: Genes Dev
Title: Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.
Volume: 26
Issue: 23
Pages: 2561-6
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Publication
24860158 | J:217846
First Author: Strohecker AM
Year: 2014
Journal: Cancer Discov
Title: Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers.
Volume: 4
Issue: 7
Pages: 766-72
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Allele
Hprt1<tm1(sb-Onco-Array)Peli> | MGI:4843327
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Pentao Liu
Allele Type: Targeted
Attribute String: RMCE-ready, Transposon concatemer
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Protein
Q61097
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Protein
Q3UVC0
Organism: Mus musculus/domesticus
Length: 959  
Fragment?: false
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Protein
Q5SXE4
Organism: Mus musculus/domesticus
Length: 637  
Fragment?: false
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Protein
A5X3G4
Organism: Mus musculus/domesticus
Length: 947  
Fragment?: false
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Protein
M0QW59
Organism: Mus musculus/domesticus
Length: 951  
Fragment?: false
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Publication
15716956 | J:96202
First Author: Carreira S
Year: 2005
Journal: Nature
Title: Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression.
Volume: 433
Issue: 7027
Pages: 764-9
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Publication
29654229 | J:261939
First Author: Oldrini B
Year: 2018
Journal: Nat Commun
Title: Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling.
Volume: 9
Issue: 1
Pages: 1466
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Publication
28514651 | J:255883
First Author: Kwong LN
Year: 2017
Journal: Cell Rep
Title: Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma.
Volume: 19
Issue: 7
Pages: 1304-1312
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Publication
22820643 | J:317304
First Author: Gembarska A
Year: 2012
Journal: Nat Med
Title: MDM4 is a key therapeutic target in cutaneous melanoma.
Volume: 18
Issue: 8
Pages: 1239-47
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Publication
33674596 | J:304975
First Author: Ischenko I
Year: 2021
Journal: Nat Commun
Title: KRAS drives immune evasion in a genetic model of pancreatic cancer.
Volume: 12
Issue: 1
Pages: 1482
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Publication
15024079 | J:89066
First Author: Goodall J
Year: 2004
Journal: Mol Cell Biol
Title: Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.
Volume: 24
Issue: 7
Pages: 2915-22
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Publication
23178117 | J:196210
First Author: Huang S
Year: 2012
Journal: Cell
Title: MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
Volume: 151
Issue: 5
Pages: 937-50
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Publication
21835307 | J:189266
First Author: Abu-Safieh L
Year: 2011
Journal: Am J Hum Genet
Title: Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms.
Volume: 89
Issue: 2
Pages: 313-9
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Publication
23069660 | J:199972
First Author: Fedorenko IV
Year: 2013
Journal: Oncogene
Title: NRAS mutant melanoma: biological behavior and future strategies for therapeutic management.
Volume: 32
Issue: 25
Pages: 3009-18
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Publication
30061422 | J:266274
First Author: Yang Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Central role of autophagic UVRAG in melanogenesis and the suntan response.
Volume: 115
Issue: 33
Pages: E7728-E7737
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Publication
31302002 | J:279873
First Author: Colomer C
Year: 2019
Journal: Mol Cell
Title: IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Volume: 75
Issue: 4
Pages: 669-682.e5
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Publication
31940493 | J:287418
First Author: Rosenbaum SR
Year: 2020
Journal: Cell Rep
Title: FOXD3 Regulates VISTA Expression in Melanoma.
Volume: 30
Issue: 2
Pages: 510-524.e6
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Publication
30471144 | J:321181
First Author: Moon H
Year: 2019
Journal: Exp Dermatol
Title: Sirt5 is dispensable for BrafV600E -mediated cutaneous melanoma development and growth in vivo.
Volume: 28
Issue: 1
Pages: 83-85
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Publication
35332119 | J:322998
First Author: Zhang P
Year: 2022
Journal: Nat Commun
Title: Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors.
Volume: 13
Issue: 1
Pages: 1588
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Publication
38092754 | J:343423
First Author: Muta Y
Year: 2023
Journal: Nat Commun
Title: Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Volume: 14
Issue: 1
Pages: 8075
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Protein
Q5SXE1
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q5SXE2
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Publication
29523762 | J:261905
First Author: Peyret V
Year: 2018
Journal: Mol Cancer Res
Title: Functional Toll-like Receptor 4 Overexpression in Papillary Thyroid Cancer by MAPK/ERK-Induced ETS1 Transcriptional Activity.
Volume: 16
Issue: 5
Pages: 833-845
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Fabp7-cre,-lacZ)3Gtm/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
17575131 | J:122413
First Author: Yang G
Year: 2007
Journal: Cancer Res
Title: Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice.
Volume: 67
Issue: 12
Pages: 5649-57
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Publication
22983396 | J:238049
First Author: Kwong LN
Year: 2012
Journal: Nat Med
Title: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.
Volume: 18
Issue: 10
Pages: 1503-10
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Publication
18472967 | J:138670
First Author: Lyustikman Y
Year: 2008
Journal: Neoplasia
Title: Constitutive activation of Raf-1 induces glioma formation in mice.
Volume: 10
Issue: 5
Pages: 501-10
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Publication
16510579 | J:106704
First Author: van Schanke A
Year: 2006
Journal: Cancer Res
Title: Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures.
Volume: 66
Issue: 5
Pages: 2608-15
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Publication
21203491 | J:167512
First Author: Shah M
Year: 2010
Journal: PLoS Genet
Title: A role for ATF2 in regulating MITF and melanoma development.
Volume: 6
Issue: 12
Pages: e1001258
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Publication
28263969 | J:243371
First Author: Yang H
Year: 2017
Journal: Oncogene
Title: Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma.
Volume: 36
Issue: 27
Pages: 3842-3851
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Publication
38182748 | J:344309
First Author: Tzenaki N
Year: 2024
Journal: Commun Biol
Title: A combined opposite targeting of p110δ PI3K and RhoA abrogates skin cancer.
Volume: 7
Issue: 1
Pages: 26
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Publication
24129679 | J:206060
First Author: Doma E
Year: 2013
Journal: Cancer Res
Title: Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK.
Volume: 73
Issue: 23
Pages: 6926-37
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Publication
23603816 | J:198505
First Author: Jameson KL
Year: 2013
Journal: Nat Med
Title: IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.
Volume: 19
Issue: 5
Pages: 626-630
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Publication
21734707 | J:287767
First Author: DeNicola GM
Year: 2011
Journal: Nature
Title: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
Volume: 475
Issue: 7354
Pages: 106-9
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Publication
29748372 | J:264288
First Author: Wang Q
Year: 2018
Journal: Cancer Res
Title: TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis.
Volume: 78
Issue: 14
Pages: 3982-3994
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Publication
29885461 | J:271171
 
First Author: Hutchenreuther J
Year: 2018
Journal: Matrix Biol
Title: Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma.
Volume: 74
Pages: 52-61
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Publication
26168233 | J:226336
First Author: Hutchenreuther J
Year: 2015
Journal: J Invest Dermatol
Title: CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis.
Volume: 135
Issue: 11
Pages: 2805-2813
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Publication
37833251 | J:344096
First Author: Hao W
Year: 2023
Journal: Cell Death Dis
Title: Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease.
Volume: 14
Issue: 10
Pages: 680
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Publication
23893239 | J:212616
First Author: Albinet V
Year: 2014
Journal: Oncogene
Title: Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.
Volume: 33
Issue: 26
Pages: 3364-73
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Publication
30987979 | J:274179
First Author: Shah R
Year: 2019
Journal: Cancer Res
Title: Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma.
Volume: 79
Issue: 8
Pages: 1799-1809
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Publication
28450382 | J:243438
First Author: Young HL
Year: 2017
Journal: J Exp Med
Title: An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
Volume: 214
Issue: 6
Pages: 1691-1710
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Publication
23222297 | J:194374
First Author: Marais R
Year: 2013
Journal: Cancer Res
Title: Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents.
Volume: 73
Issue: 3
Pages: 1046-9
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Publication
25597784 | J:219971
First Author: Strickland LR
Year: 2015
Journal: Cancer Lett
Title: Targeting drivers of melanoma with synthetic small molecules and phytochemicals.
Volume: 359
Issue: 1
Pages: 20-35
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Publication
25395294 | J:220618
First Author: Wargo JA
Year: 2014
Journal: Cancer Discov
Title: Universes collide: combining immunotherapy with targeted therapy for cancer.
Volume: 4
Issue: 12
Pages: 1377-86
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Publication
26603897 | J:227251
First Author: Feng Y
Year: 2015
Journal: Cancer Res
Title: SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Volume: 75
Issue: 24
Pages: 5211-8
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Publication
25026375 | J:230126
 
First Author: Mehrotra A
Year: 2014
Journal: Arch Biochem Biophys
Title: Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.
Volume: 563
Pages: 125-35
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Publication
31351087 | J:278931
 
First Author: Laudisi F
Year: 2019
Journal: Cancer Lett
Title: Induction of endoplasmic reticulum stress and inhibition of colon carcinogenesis by the anti-helmintic drug rafoxanide.
Volume: 462
Pages: 1-11
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Publication
31065107 | J:303002
First Author: Laurette P
Year: 2020
Journal: Cell Death Differ
Title: Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
Volume: 27
Issue: 1
Pages: 29-43
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Publication
34210801 | J:308465
 
First Author: Bowman RL
Year: 2021
Journal: Life Sci Alliance
Title: UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma.
Volume: 4
Issue: 9
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Publication
33743547 | J:307675
First Author: Kanazawa K
Year: 2021
Journal: Cancer Sci
Title: Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
Volume: 112
Issue: 6
Pages: 2233-2244
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Publication
32629543 | J:313360
First Author: Kochi M
Year: 2020
Journal: Cancer Sci
Title: Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer.
Volume: 111
Issue: 10
Pages: 3540-3549
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Publication
37870961 | J:342136
 
First Author: SĂ¡nchez-TillĂ³ E
Year: 2023
Journal: JCI Insight
Title: The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas.
Volume: 8
Issue: 20
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Publication
23372702 | J:195921
First Author: Ryder M
Year: 2013
Journal: PLoS One
Title: Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.
Volume: 8
Issue: 1
Pages: e54302
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Publication
25246427 | J:264174
First Author: Kaul A
Year: 2015
Journal: Neuro Oncol
Title: The impact of coexisting genetic mutations on murine optic glioma biology.
Volume: 17
Issue: 5
Pages: 670-7
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Publication
19064922 | J:166283
First Author: Su Q
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A DNA transposon-based approach to validate oncogenic mutations in the mouse.
Volume: 105
Issue: 50
Pages: 19904-9
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hprt1/Hprt1<+>
Background: involves: 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hprt1/?
Background: involves: 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ifi208/Ifi208<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
28192409 | J:243383
First Author: Tonks ID
Year: 2017
Journal: Oncogene
Title: Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation.
Volume: 36
Issue: 26
Pages: 3789-3795
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Publication
22643351 | J:292907
First Author: Bongers G
Year: 2012
Journal: Gastroenterology
Title: A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.
Volume: 143
Issue: 3
Pages: 730-740
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Publication
37415974 | J:337739
 
First Author: Jacenik D
Year: 2023
Journal: Front Immunol
Title: MK2 drives progression of pancreas and colon cancers by suppressing CD8(+) T cell cytotoxic function and is a potential immunotherapy target.
Volume: 14
Pages: 1212100
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Protein
A0A140LHS5
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: true
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Publication
17586814 | J:133638
First Author: Hitz C
Year: 2007
Journal: Nucleic Acids Res
Title: Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference.
Volume: 35
Issue: 12
Pages: e90
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Protein
Q3U2C5
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Protein
A0A2I3BR95
Organism: Mus musculus/domesticus
Length: 818  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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