RapGEF2 (CNrasGEF) is a Rap guanine nucleotide exchange factor that specifically activates Rap1 []. It is involved in embryonic hematopoiesis [], proper development of the midline commissures []and neuronal migration in the developing cerebral cortex []. It functions in the cAMP-induced Erk signalling pathway that leads to neuritogenesis []. It has a role in regulating cell proliferation and apoptosis [].
