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Search results 701 to 800 out of 834 for Vldlr

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Type Details Score
Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
32072135 | J:285364
First Author: Lee SD
Year: 2019
Journal: Nat Metab
Title: IDOL regulates systemic energy balance through control of neuronal VLDLR expression.
Volume: 1
Issue: 11
Pages: 1089-1100
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GXD Expression
GXD Expression
 
Probe: MGI:6295196
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6295390
Age: embryonic day 15.5
Note: Co-localization of staining with Vldlr was noted.
Specimen Label: 3H
Detected: true
Specimen Num: 3
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Publication
12093079 | J:78001
First Author: Drakew A
Year: 2002
Journal: Exp Neurol
Title: Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice.
Volume: 176
Issue: 1
Pages: 12-24
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Pathway
R-MMU-8866427 | VLDLR internalisation and degradation
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Allele
Vldlr<em1Smoc> | MGI:7293136
Name: very low density lipoprotein receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GO Term
GO:0070326 | very-low-density lipoprotein particle receptor binding
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DO Term
DOID:0050997 | cerebellar ataxia, mental retardation and dysequlibrium syndrome
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Publication
20427281 | -
First Author: Hong C
Year: 2010
Journal: J Biol Chem
Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
Volume: 285
Issue: 26
Pages: 19720-6
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HT Experiment
GSE94896 | Expression data from 3 different Reeler mouse models
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:0110157 | reelin complex
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Publication
10571240 | J:180496
First Author: D'Arcangelo G
Year: 1999
Journal: Neuron
Title: Reelin is a ligand for lipoprotein receptors.
Volume: 24
Issue: 2
Pages: 471-9
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Protein Coding Gene
MGI:2388271 | Mylip
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BM54
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Allele
Vldlr<m2Btlr> | MGI:6197824
Name: very low density lipoprotein receptor; mutation 2, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6197836 | C57BL/6J-Vldlr<m2Btlr>
Attribute String: coisogenic, chemically induced mutation, mutant strain
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Genotype
Genotype
Symbol: Vldlr/Vldlr
Background: C57BL/6J-Vldlr
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
E-MEXP-3323 | Retinal vessel microarray
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:2140260 | Pcsk9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80W65
Organism: Mus musculus/domesticus
Length: 694  
Fragment?: false
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Protein Coding Gene
MGI:1352462 | Nr1h3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1352463 | Nr1h2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60644
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q9Z0Y9
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
F6U2B2
Organism: Mus musculus/domesticus
Length: 47  
Fragment?: true
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Protein Domain
IPR034968 | Reelin
Type: Family
Description: Reelin is an extracellular matrix serine protease that regulates neuronal migration during embryonic development and acts as a modulator of synaptic transmission in the adult brain []. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons [, , ]. In the adult brain, reelin stabilizes the actin cytoskeleton by inducing cofilin phosphorylation. Decreased Reelin expression causes destabilization of neurons, which could have implications for brain disorders, such as epilepsy and schizophrenia [].
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Publication
20525064 | -
First Author: Förster E
Year: 2010
Journal: Eur J Neurosci
Title: Emerging topics in Reelin function.
Volume: 31
Issue: 9
Pages: 1511-8
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Publication
19396394 | -
First Author: Frotscher M
Year: 2009
Journal: J Neural Transm (Vienna)
Title: Role of Reelin in the development and maintenance of cortical lamination.
Volume: 116
Issue: 11
Pages: 1451-5
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Publication
20598379 | -
First Author: Frotscher M
Year: 2010
Journal: Trends Neurosci
Title: Role for Reelin in stabilizing cortical architecture.
Volume: 33
Issue: 9
Pages: 407-14
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Protein Coding Gene
MGI:1919020 | Ap2b1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2388633 | Cltc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1298405 | Ap2m1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894297 | Clta
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2141861 | Ap2s1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101921 | Ap2a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101920 | Ap2a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P17427
Organism: Mus musculus/domesticus
Length: 938  
Fragment?: false
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Protein
P17426
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
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Protein
Q9DBG3
Organism: Mus musculus/domesticus
Length: 937  
Fragment?: false
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Protein
P62743
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
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Protein
P84091
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
Q68FD5
Organism: Mus musculus/domesticus
Length: 1675  
Fragment?: false
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Protein
O08585
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Publication
18029196 | J:132599
First Author: Pramatarova A
Year: 2008
Journal: Mol Cell Neurosci
Title: A genetic interaction between the APP and Dab1 genes influences brain development.
Volume: 37
Issue: 1
Pages: 178-86
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Publication
18842893 | J:141125
First Author: Niu S
Year: 2008
Journal: J Neurosci
Title: The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons.
Volume: 28
Issue: 41
Pages: 10339-48
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Publication
37188781 | J:341134
First Author: Lopera F
Year: 2023
Journal: Nat Med
Title: Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man.
Volume: 29
Issue: 5
Pages: 1243-1252
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Publication
14715136 | J:87427
First Author: Niu S
Year: 2004
Journal: Neuron
Title: Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway.
Volume: 41
Issue: 1
Pages: 71-84
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Publication
8020981 | J:17416
First Author: Oka K
Year: 1994
Journal: Genomics
Title: Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9p24 by fluorescence in situ hybridization.
Volume: 20
Issue: 2
Pages: 298-300
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Publication
15883038 | J:98290
First Author: Huang Y
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Signaling through Disabled 1 requires phosphoinositide binding.
Volume: 331
Issue: 4
Pages: 1460-8
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Publication
31831824 | J:297846
First Author: Mikulska-Ruminska K
Year: 2019
Journal: Sci Rep
Title: Dynamics, nanomechanics and signal transduction in reelin repeats.
Volume: 9
Issue: 1
Pages: 18974
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Protein Domain
IPR041161 | EGF_Tenascin
Type: Domain
Description: This entry represents the EGF-like domains found in Tenascin and Reelin proteins. A common feature of all EGF-like domains is that they are found in theextracellular domain of membrane-bound proteins or in proteins known to besecreted (exception: prostaglandin G/H synthase). The EGF-like domain includessix cysteine residues which have been shown to be involved in disulfide bonds.The structure of several EGF-like domains has been solved. The fold consistsof two-stranded β-sheet followed by a loop to a C-terminal shorttwo-stranded sheet []. Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions to regulate cell adhesion, migration, proliferation and differentiation. Tenascins are usually composed of repeated epidermal growth factor (EGF)-like domains, fibronectin-type III (FNIII) domains and a C-terminal fibrinogen related domain (FReD) [].Reelin is an extracellular matrix serine protease that regulates neuronal migration during embryonic development and acts as a modulator of synaptic transmission in the adult brain []. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons [, , ]. In the adult brain, reelin stabilizes the actin cytoskeleton by inducing cofilin phosphorylation. Decreased Reelin expression causes destabilization of neurons, which could have implications for brain disorders, such as epilepsy and schizophrenia [].
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Publication
22481440 | J:186215
First Author: Kysenius K
Year: 2012
Journal: Cell Mol Life Sci
Title: PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling.
Volume: 69
Issue: 11
Pages: 1903-16
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Publication
10959835 | J:79475
First Author: Howell BW
Year: 2000
Journal: Curr Biol
Title: Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development.
Volume: 10
Issue: 15
Pages: 877-85
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Publication
12077184 | J:77532
First Author: Keshvara L
Year: 2002
Journal: J Neurosci
Title: Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
Volume: 22
Issue: 12
Pages: 4869-77
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Publication
21885617 | J:183568
First Author: Gulsuner S
Year: 2011
Journal: Genome Res
Title: Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred.
Volume: 21
Issue: 12
Pages: 1995-2003
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Publication
14559149 | J:115650
First Author: Ballif BA
Year: 2003
Journal: Brain Res Mol Brain Res
Title: Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases.
Volume: 117
Issue: 2
Pages: 152-9
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Publication
16438943 | J:106956
 
First Author: Isosaka T
Year: 2006
Journal: Brain Res
Title: NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice.
Volume: 1073-1074
Pages: 11-9
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Publication
32244519 | J:301023
 
First Author: Cawley NX
Year: 2020
Journal: Int J Mol Sci
Title: Evaluation of the Potential Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Niemann-Pick Disease, Type C1.
Volume: 21
Issue: 7
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Publication
20566868 | J:162071
First Author: Tan XJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering.
Volume: 107
Issue: 27
Pages: 12305-10
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Publication
16723719 | J:109123
First Author: MacDougall ED
Year: 2006
Journal: Am J Pathol
Title: Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice.
Volume: 168
Issue: 6
Pages: 2064-73
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Publication
24068831 | J:202682
First Author: Trotter J
Year: 2013
Journal: J Neurosci
Title: Dab1 is required for synaptic plasticity and associative learning.
Volume: 33
Issue: 39
Pages: 15652-68
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Publication
29289645 | J:264988
 
First Author: Zarei M
Year: 2018
Journal: Mol Metab
Title: Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease.
Volume: 8
Pages: 117-131
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Publication
22351125 | J:187338
First Author: Yip YP
Year: 2012
Journal: J Comp Neurol
Title: Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.
Volume: 520
Issue: 14
Pages: 3194-202
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Publication
31230943 | J:289855
 
First Author: Roberts BL
Year: 2019
Journal: Mol Metab
Title: Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons.
Volume: 26
Pages: 18-29
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Publication
26812621 | J:257390
First Author: Tuong ZK
Year: 2016
Journal: PLoS One
Title: RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.
Volume: 11
Issue: 1
Pages: e0147179
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Publication
9346319 | J:43030
First Author: Martensen PM
Year: 1997
Journal: Eur J Biochem
Title: Breast carcinoma epithelial cells express a very low-density lipoprotein receptor variant lacking the O-linked glycosylation domain encoded by exon 16, but with full binding activity for serine proteinase/serpin complexes and Mr-40,000 receptor-associated protein.
Volume: 248
Issue: 2
Pages: 583-91
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Publication
19805234 | J:153241
First Author: Durakoglugil MS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Reelin signaling antagonizes beta-amyloid at the synapse.
Volume: 106
Issue: 37
Pages: 15938-43
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Publication
32083308 | J:303676
First Author: Hamad MIK
Year: 2021
Journal: J Neurochem
Title: Reelin signaling modulates GABAB receptor function in the neocortex.
Volume: 156
Issue: 5
Pages: 589-603
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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