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Search results 1 to 100 out of 285 for Eif2ak4

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Hits by Strain

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Type Details Score
Gene
440275 | EIF2AK4
Type: gene
Organism: human
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Gene
513829 | EIF2AK4
Type: gene
Organism: cattle
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Gene
423285 | EIF2AK4
Type: gene
Organism: chicken
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Gene
100149925 | eif2ak4
Type: gene
Organism: zebrafish
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Gene
100428309 | EIF2AK4
Type: gene
Organism: macaque, rhesus
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Gene
100216307 | eif2ak4
Type: gene
Organism: frog, western clawed
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Gene
114859 | Eif2ak4
Type: gene
Organism: rat
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Gene
478257 | EIF2AK4
Type: gene
Organism: dog, domestic
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Gene
453321 | EIF2AK4
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1353427 | Eif2ak4
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
10985 | GCN1
Type: gene
Organism: human
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Publication
23447528 | J:197824
First Author: Roffé M
Year: 2013
Journal: J Biol Chem
Title: IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
Volume: 288
Issue: 15
Pages: 10860-9
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Publication
24333428 | J:211861
First Author: Cambiaghi TD
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Volume: 443
Issue: 2
Pages: 592-7
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Publication
15937339 | J:100824
First Author: Pereira CM
Year: 2005
Journal: J Biol Chem
Title: IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.
Volume: 280
Issue: 31
Pages: 28316-23
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Publication
32324833 | J:287528
First Author: Yamazaki H
Year: 2020
Journal: PLoS Genet
Title: Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
Volume: 16
Issue: 4
Pages: e1008693
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Publication
32376799 | J:301914
 
First Author: Kanno A
Year: 2020
Journal: JCI Insight
Title: GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.
Volume: 5
Issue: 9
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Publication
- | J:173669
     
First Author: Beutler B
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2011/07/19
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Gene
690632 | Gcn1
Type: gene
Organism: rat
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Gene
477505 | GCN1
Type: gene
Organism: dog, domestic
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Gene
742053 | GCN1
Type: gene
Organism: chimpanzee
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Gene
536143 | GCN1
Type: gene
Organism: cattle
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Gene
567890 | gcn1
Type: gene
Organism: zebrafish
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Gene
698528 | GCN1
Type: gene
Organism: macaque, rhesus
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Publication
30120269 | J:279276
First Author: Bretin A
Year: 2018
Journal: Sci Rep
Title: AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation.
Volume: 8
Issue: 1
Pages: 12301
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Publication
22114338 | J:179383
First Author: Won S
Year: 2012
Journal: J Virol
Title: Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.
Volume: 86
Issue: 3
Pages: 1802-8
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Protein Coding Gene
MGP_CAROLIEiJ_G0024115 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026314 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026275 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026034 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1353427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026735 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026010 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026250 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026130 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026790 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025232 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025558 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025031 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10504407 | J:58015
First Author: Berlanga JJ
Year: 1999
Journal: Eur J Biochem
Title: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.
Volume: 265
Issue: 2
Pages: 754-62
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Publication
10655230 | J:71261
First Author: Sood R
Year: 2000
Journal: Genetics
Title: A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.
Volume: 154
Issue: 2
Pages: 787-801
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Publication
12215525 | J:78945
First Author: Zhang P
Year: 2002
Journal: Mol Cell Biol
Title: The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.
Volume: 22
Issue: 19
Pages: 6681-8
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Publication
15213227 | J:92545
First Author: Anthony TG
Year: 2004
Journal: J Biol Chem
Title: Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.
Volume: 279
Issue: 35
Pages: 36553-61
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Publication
16054071 | J:129841
First Author: Maurin AC
Year: 2005
Journal: Cell Metab
Title: The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.
Volume: 1
Issue: 4
Pages: 273-7
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Publication
16121183 | J:100646
First Author: Costa-Mattioli M
Year: 2005
Journal: Nature
Title: Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2.
Volume: 436
Issue: 7054
Pages: 1166-73
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Publication
16601681 | J:227388
First Author: Berlanga JJ
Year: 2006
Journal: EMBO J
Title: Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses.
Volume: 25
Issue: 8
Pages: 1730-40
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Publication
1739968 | J:113815
First Author: Dever TE
Year: 1992
Journal: Cell
Title: Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.
Volume: 68
Issue: 3
Pages: 585-96
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Publication
16709834 | J:131797
First Author: Fallarino F
Year: 2006
Journal: J Immunol
Title: The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.
Volume: 176
Issue: 11
Pages: 6752-61
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Publication
24166753 | J:280763
First Author: Lu Z
Year: 2014
Journal: Hypertension
Title: Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy.
Volume: 63
Issue: 1
Pages: 128-35
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Publication
22277968 | J:183697
First Author: Peng W
Year: 2012
Journal: Sci Transl Med
Title: Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.
Volume: 4
Issue: 118
Pages: 118ra11
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Publication
27558825 | J:239028
First Author: Leib DE
Year: 2016
Journal: Cell Rep
Title: Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2.
Volume: 16
Issue: 8
Pages: 2051-2052
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Publication
31875620 | J:289064
First Author: Sun ZG
Year: 2020
Journal: Int Heart J
Title: Exercise Preconditioning Protects against Acute Cardiac Injury Induced by Lipopolysaccharide Through General Control Nonderepressible 2 Kinase.
Volume: 61
Issue: 1
Pages: 138-144
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Publication
33299856 | J:309506
 
First Author: Luo X
Year: 2020
Journal: Biomed Res Int
Title: GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis.
Volume: 2020
Pages: 1454396
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Publication
30006154 | J:270286
First Author: Liu S
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice.
Volume: 1864
Issue: 10
Pages: 3257-3267
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Publication
31121187 | J:295489
First Author: Wang P
Year: 2019
Journal: J Allergy Clin Immunol
Title: The amino acid sensor general control nonderepressible 2 (GCN2) controls TH9 cells and allergic airway inflammation.
Volume: 144
Issue: 4
Pages: 1091-1105
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Publication
25491724 | J:219631
First Author: Wilson GJ
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.
Volume: 308
Issue: 4
Pages: E283-93
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Publication
24146979 | J:209106
First Author: Devi L
Year: 2013
Journal: PLoS One
Title: Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.
Volume: 8
Issue: 10
Pages: e77335
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Publication
35803229 | J:337218
First Author: Li C
Year: 2022
Journal: Cell Stem Cell
Title: Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis.
Volume: 29
Issue: 7
Pages: 1119-1134.e7
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Publication
25406192 | J:217476
First Author: Fletcher M
Year: 2015
Journal: Cancer Res
Title: l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells.
Volume: 75
Issue: 2
Pages: 275-83
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Publication
23318883 | J:314788
First Author: Arriazu E
Year: 2013
Journal: Lab Invest
Title: GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice.
Volume: 93
Issue: 3
Pages: 303-10
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Publication
38175755 | J:344406
First Author: Hou Y
Year: 2024
Journal: Cell Rep
Title: Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes.
Volume: 43
Issue: 1
Pages: 113658
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Publication
21239484 | J:170634
First Author: Marion V
Year: 2011
Journal: J Biol Chem
Title: Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2.
Volume: 286
Issue: 11
Pages: 8866-74
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Publication
26526991 | J:228969
First Author: Leib DE
Year: 2015
Journal: Cell Rep
Title: Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism.
Volume: 13
Issue: 6
Pages: 1081-1089
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Publication
32253314 | J:293889
First Author: Kim Y
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Volume: 117
Issue: 16
Pages: 8900-8911
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Publication
22509023 | J:183917
First Author: Ye J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
Volume: 109
Issue: 18
Pages: 6904-9
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Publication
20807889 | J:167423
First Author: Highfill SL
Year: 2010
Journal: Blood
Title: Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Volume: 116
Issue: 25
Pages: 5738-47
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Publication
27397084 | J:325830
 
First Author: Keil M
Year: 2016
Journal: J Neuroimmunol
Title: General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.
Volume: 297
Pages: 117-26
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Publication
22517796 | J:201245
First Author: Iken K
Year: 2012
Journal: Am J Respir Cell Mol Biol
Title: Indoleamine 2,3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells.
Volume: 47
Issue: 4
Pages: 405-16
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Publication
17276353 | J:129768
First Author: Guo F
Year: 2007
Journal: Cell Metab
Title: The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.
Volume: 5
Issue: 2
Pages: 103-14
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Publication
24130751 | J:209123
First Author: Xu X
Year: 2013
Journal: PLoS One
Title: GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.
Volume: 8
Issue: 10
Pages: e75917
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Publication
20861212 | J:165413
First Author: Bunpo P
Year: 2010
Journal: J Nutr
Title: The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.
Volume: 140
Issue: 11
Pages: 2020-7
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Publication
32453500 | J:318910
First Author: Hu G
Year: 2020
Journal: J Bone Miner Res
Title: The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice.
Volume: 35
Issue: 10
Pages: 2004-2014
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Publication
23775766 | J:208953
First Author: Yu J
Year: 2013
Journal: Diabetes
Title: PRLR regulates hepatic insulin sensitivity in mice via STAT5.
Volume: 62
Issue: 9
Pages: 3103-13
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Publication
24002574 | J:203826
First Author: Wilson GJ
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.
Volume: 305
Issue: 9
Pages: E1124-33
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Publication
35690926 | J:329516
First Author: Jonsson WO
Year: 2022
Journal: FASEB J
Title: Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific.
Volume: 36
Issue: 7
Pages: e22396
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Publication
31573843 | J:282895
First Author: Chalvon-Demersay T
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Liver GCN2 controls hepatic FGF21 secretion and modulates whole body postprandial oxidation profile under a low-protein diet.
Volume: 317
Issue: 6
Pages: E1015-E1021
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Publication
26968207 | J:234729
First Author: Phillipson-Weiner L
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.
Volume: 310
Issue: 11
Pages: G1061-70
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Publication
34740902 | J:319528
First Author: Yin H
Year: 2022
Journal: Diabetes
Title: Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression.
Volume: 71
Issue: 2
Pages: 206-218
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GXD Expression
GXD Expression
     
Probe: MGI:4366299
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366300
Age: postnatal day 25
Specimen Label: Oo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4366299
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Absent
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366300
Age: postnatal day 25
Specimen Label: B
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Absent
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366304
Age: postnatal day 25
Specimen Label: Oo
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366304
Age: postnatal day 25
Specimen Label: B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366304
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366304
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366305
Age: postnatal day 25
Specimen Label: Oo
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366305
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366305
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366305
Age: postnatal day 25
Specimen Label: B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Absent
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366306
Age: postnatal day 25
Specimen Label: Oo
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366306
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366306
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366306
Age: postnatal day 25
Specimen Label: B
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366307
Age: postnatal day 25
Specimen Label: Oo
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366307
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366307
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
•
•
•
•
•




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