CD2-associated protein (CD2AP) may function in dynamic actin remodelling and membrane trafficking during endocytosis []. During late anaphase and telophase, it localises to the microtubule midzone and telophase midbody. It may also play an role in cytokinesis [].
CD2AP is a multifunctional adaptor protein involved in membrane trafficking, dynamic actin remodelling and endocytosis [, ]. CD2AP contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. Different biological processes regulated by CD2AP require specific binding partners [].This entry represents the third SH3 domain (SH3C) of CD2AP. SH3C has been shown to bind ubiquitin [].
CD2AP is a multifunctional adaptor protein involved in membrane trafficking, dynamic actin remodelling and endocytosis [, ]. CD2AP contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. Different biological processes regulated by CD2AP require specific binding partners [].This entry represents the first SH3 domain (SH3A). It binds to the PXXXPR motif present in c-Cbl and the cytoplasmic domain of cell adhesion protein CD2 [].
CD2AP is a multifunctional adaptor protein involved in membrane trafficking, dynamic actin remodelling and endocytosis [, ]. CD2AP contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. Different biological processes regulated by CD2AP require specific binding partners [].This entry represents the second SH3 domain (SH3B) of CD2AP. SH3B binds to c-Cbl in a site (TPSSRPLR is the core binding motif) distinct from the c-Cbl/SH3A binding site [].
