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Search results 101 to 108 out of 108 for Orc3

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Type

Details

Score

Publication

31160578 | -

First Author:	Coulombe P
Year:	2019
Journal:	Nat Commun
Title:	The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.
Volume:	10
Issue:	1
Pages:	2426

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Protein Domain

IPR039209 | OBI1

Type:	Family
Description:	This family describes ORC ubiquitin ligase 1 (previously known as RING finger protein 219 or RNF219). ORC ubiquitin ligase 1 is an E3 ubiquitin ligase essential for DNA replication origin activation during S phase. It functions as a replication origin selector and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase [].

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Protein Domain

IPR045663 | ORC3_ins

Type:

Domain

Description:

This is the insertion domain of ORC subunit 3 (ORC3) predominantly found in chodates, arthropodes and vertebrates, located between the N-terminal AAA+-like subunit and the C-terminal winged-helix (WH) DNA-binding domain []. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This insertion domain forms a bi-lobed α-helical protuberancethat engages a short α-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits [], which constitute the ORC core [, ].

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Publication

25762138 | -

First Author:	Bleichert F
Year:	2015
Journal:	Nature
Title:	Crystal structure of the eukaryotic origin recognition complex.
Volume:	519
Issue:	7543
Pages:	321-6

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Publication

28112645 | -

First Author:	Tocilj A
Year:	2017
Journal:	Elife
Title:	Structure of the active form of human origin recognition complex and its ATPase motor module.
Volume:	6

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Protein

Q8K2Y0

Organism:	Mus musculus/domesticus
Length:	722
Fragment?:	false

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Protein

G3X8V5

Organism:	Mus musculus/domesticus
Length:	722
Fragment?:	false

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Protein

A0A2I3BRT6

Organism:	Mus musculus/domesticus
Length:	235
Fragment?:	false

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