Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase that has dual hydrolase and ligase activities []. It is the most abundant protein in brain lysates (1-2%), regulating the timing and the pattern of ubiquitination []. Mutations in the UCHL1 gene has been linked to neurodegenerative diseases [, ]. UCHL1 also pays a major role in oncogenesis [].
