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Search results 1 to 100 out of 171 for Nr1i3

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Category: Publication
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Type Details Score
Publication
12376703 | J:83102
First Author: Zhang J
Year: 2002
Journal: Science
Title: Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.
Volume: 298
Issue: 5592
Pages: 422-4
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Publication
15272053 | J:272540
First Author: Huang W
Year: 2004
Journal: Mol Endocrinol
Title: Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.
Volume: 18
Issue: 10
Pages: 2402-8
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Publication
12644704 | J:82748
First Author: Huang W
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Induction of bilirubin clearance by the constitutive androstane receptor (CAR).
Volume: 100
Issue: 7
Pages: 4156-61
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Publication
19489075 | J:270973
First Author: Dong B
Year: 2009
Journal: Hepatology
Title: Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes.
Volume: 50
Issue: 2
Pages: 622-9
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Publication
9295294 | J:43027
First Author: Choi HS
Year: 1997
Journal: J Biol Chem
Title: Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR.
Volume: 272
Issue: 38
Pages: 23565-71
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Publication
11057673 | J:65416
First Author: Wei P
Year: 2000
Journal: Nature
Title: The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism.
Volume: 407
Issue: 6806
Pages: 920-3
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Publication
25404284 | J:216278
First Author: Yueh MF
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: The commonly used antimicrobial additive triclosan is a liver tumor promoter.
Volume: 111
Issue: 48
Pages: 17200-5
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Publication
26928356 | J:254692
First Author: Kuwata K
Year: 2016
Journal: Toxicol Sci
Title: Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Volume: 151
Issue: 2
Pages: 271-85
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Publication
28350814 | J:247967
First Author: Kumar R
Year: 2017
Journal: PLoS One
Title: Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice.
Volume: 12
Issue: 3
Pages: e0174355
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Publication
22761658 | J:187925
First Author: Yueh MF
Year: 2012
Journal: PLoS One
Title: Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha.
Volume: 7
Issue: 6
Pages: e37705
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Publication
27240521 | J:236812
First Author: Boussadia B
Year: 2016
Journal: Exp Neurol
Title: Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Volume: 283
Issue: Pt A
Pages: 39-48
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Publication
21335546 | J:171103
First Author: GarcĂ­a A
Year: 2011
Journal: Cancer Res
Title: Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response.
Volume: 71
Issue: 7
Pages: 2529-40
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Publication
11752199 | J:142490
First Author: Ueda A
Year: 2002
Journal: Mol Pharmacol
Title: Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital.
Volume: 61
Issue: 1
Pages: 1-6
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Publication
29351922 | J:276199
First Author: Choi YJ
Year: 2018
Journal: Mol Pharmacol
Title: Activation of Constitutive Androstane Receptor Ameliorates Renal Ischemia-Reperfusion-Induced Kidney and Liver Injury.
Volume: 93
Issue: 3
Pages: 239-250
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Publication
21519326 | J:174149
First Author: Chen X
Year: 2011
Journal: Lab Invest
Title: The nuclear receptor CAR modulates alcohol-induced liver injury.
Volume: 91
Issue: 8
Pages: 1136-45
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Publication
15831521 | J:98536
First Author: Huang W
Year: 2005
Journal: Mol Endocrinol
Title: Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
Volume: 19
Issue: 6
Pages: 1646-53
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Publication
21698271 | J:174781
First Author: Sueyoshi T
Year: 2011
Journal: PLoS One
Title: Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.
Volume: 6
Issue: 6
Pages: e21229
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Publication
31882815 | J:306731
First Author: Lukowicz C
Year: 2019
Journal: Sci Rep
Title: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor.
Volume: 9
Issue: 1
Pages: 20169
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Publication
24824808 | J:212906
First Author: Maeda J
Year: 2014
Journal: Toxicol Sci
Title: In vivo genotoxicity of Ginkgo biloba extract in gpt delta mice and constitutive androstane receptor knockout mice.
Volume: 140
Issue: 2
Pages: 298-306
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Publication
28422158 | J:323497
 
First Author: Yoda E
Year: 2017
Journal: Sci Rep
Title: Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.
Volume: 7
Pages: 46489
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Publication
27853109 | J:320499
First Author: Tamura K
Year: 2016
Journal: J Toxicol Sci
Title: A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice.
Volume: 41
Issue: 6
Pages: 801-811
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Publication
21672546 | J:174961
First Author: Smetanina MA
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.
Volume: 255
Issue: 1
Pages: 76-85
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Publication
28265001 | J:243837
 
First Author: Shizu R
Year: 2017
Journal: Mol Cell Biol
Title: Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation.
Volume: 37
Issue: 10
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Publication
16950832 | J:135857
First Author: Yamazaki Y
Year: 2007
Journal: Gut
Title: The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis.
Volume: 56
Issue: 4
Pages: 565-74
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Publication
23152187 | J:206910
First Author: Zhang YK
Year: 2013
Journal: Toxicol Sci
Title: Expression of human CAR splicing variants in BAC-transgenic mice.
Volume: 132
Issue: 1
Pages: 142-50
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Publication
21173431 | J:170378
First Author: Takizawa D
Year: 2011
Journal: Carcinogenesis
Title: Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
Volume: 32
Issue: 4
Pages: 576-83
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Publication
33154041 | J:344684
First Author: Weber AA
Year: 2021
Journal: Drug Metab Dispos
Title: Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation.
Volume: 49
Issue: 1
Pages: 12-19
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Publication
15492232 | J:93651
First Author: Yamamoto Y
Year: 2004
Journal: Cancer Res
Title: The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.
Volume: 64
Issue: 20
Pages: 7197-200
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Publication
24114688 | J:317937
First Author: Cho HY
Year: 2014
Journal: J Cell Physiol
Title: In vivo deletion of CAR resulted in high bone mass phenotypes in male mice.
Volume: 229
Issue: 5
Pages: 561-71
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Publication
18441373 | J:138452
First Author: Masson D
Year: 2008
Journal: J Lipid Res
Title: Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice.
Volume: 49
Issue: 8
Pages: 1682-91
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Publication
12181440 | J:90553
First Author: Maglich JM
Year: 2002
Journal: Mol Pharmacol
Title: Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
Volume: 62
Issue: 3
Pages: 638-46
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Publication
15004031 | J:89824
First Author: Maglich JM
Year: 2004
Journal: J Biol Chem
Title: The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.
Volume: 279
Issue: 19
Pages: 19832-8
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Publication
27434302 | J:248735
First Author: de Vries EM
Year: 2016
Journal: PLoS One
Title: Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR.
Volume: 11
Issue: 7
Pages: e0159552
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Publication
26187448 | J:337260
First Author: Wang Z
Year: 2015
Journal: Toxicol Sci
Title: Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors.
Volume: 147
Issue: 2
Pages: 549-61
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Publication
29996089 | J:270784
First Author: Lavi K
Year: 2018
Journal: Cell Rep
Title: Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits.
Volume: 24
Issue: 2
Pages: 278-283
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28947831 | J:256538
First Author: Saez-Lopez C
Year: 2017
Journal: Sci Rep
Title: Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox.
Volume: 7
Issue: 1
Pages: 12284
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Publication
11039937 | J:65418
First Author: Vasquez KM
Year: 2000
Journal: Science
Title: Specific mutations induced by triplex-forming oligonucleotides in mice.
Volume: 290
Issue: 5491
Pages: 530-3
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Publication
12554751 | J:81621
First Author: Andersin T
Year: 2003
Journal: Mol Endocrinol
Title: The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor.
Volume: 17
Issue: 2
Pages: 234-46
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Publication
14988430 | J:91347
First Author: Swales K
Year: 2004
Journal: Mol Endocrinol
Title: CAR, driving into the future.
Volume: 18
Issue: 7
Pages: 1589-98
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Publication
15610734 | J:95629
First Author: Shan L
Year: 2004
Journal: Mol Cell
Title: Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism.
Volume: 16
Issue: 6
Pages: 907-17
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Publication
17355985 | J:121881
First Author: Stoner MA
Year: 2007
Journal: Nucleic Acids Res
Title: Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.
Volume: 35
Issue: 7
Pages: 2177-90
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Publication
19858220 | J:157027
First Author: Mutoh S
Year: 2009
Journal: J Biol Chem
Title: Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).
Volume: 284
Issue: 50
Pages: 34785-92
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Publication
24498295 | J:225163
First Author: Yao R
Year: 2014
Journal: PLoS One
Title: Nuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages.
Volume: 9
Issue: 2
Pages: e87142
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Publication
27530923 | J:238939
First Author: Yarushkin AA
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Constitutive androstane receptor activation evokes the expression of glycolytic genes.
Volume: 478
Issue: 3
Pages: 1099-105
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Publication
28283178 | J:241938
First Author: Cheng S
Year: 2017
Journal: Am J Pathol
Title: Activation of Constitutive Androstane Receptor Prevents Cholesterol Gallstone Formation.
Volume: 187
Issue: 4
Pages: 808-818
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Publication
28903501 | J:257715
First Author: Lodato NJ
Year: 2017
Journal: Toxicol Sci
Title: Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.
Volume: 159
Issue: 1
Pages: 25-41
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Publication
27080131 | J:251112
First Author: Hao R
Year: 2016
Journal: Biochim Biophys Acta
Title: Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.
Volume: 1859
Issue: 9
Pages: 1228-37
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Publication
- | J:93013
     
First Author: Negishi M
Year: 2004
Journal: Personal Communication
Title: CAR Knockout construct
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Publication
8603043 | J:57555
First Author: Choi HS
Year: 1996
Journal: J Steroid Biochem Mol Biol
Title: A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily.
Volume: 56
Issue: 1-6 Spec No
Pages: 23-30
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Publication
17904126 | J:126925
First Author: Hosseinpour F
Year: 2007
Journal: FEBS Lett
Title: Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver.
Volume: 581
Issue: 25
Pages: 4937-42
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Publication
21424122 | J:184955
First Author: Kamino H
Year: 2011
Journal: Int J Oncol
Title: Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.
Volume: 38
Issue: 6
Pages: 1511-20
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Publication
21872825 | J:200136
First Author: Kamino H
Year: 2011
Journal: Cancer Genet
Title: Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.
Volume: 204
Issue: 7
Pages: 382-91
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Publication
29716964 | J:263993
First Author: Hori T
Year: 2018
Journal: Mol Cancer Res
Title: Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver.
Volume: 16
Issue: 8
Pages: 1309-1318
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Publication
8650544 | J:33440
First Author: Seol W
Year: 1996
Journal: Science
Title: An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors.
Volume: 272
Issue: 5266
Pages: 1336-9
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Publication
15619241 | J:105336
First Author: Uppal H
Year: 2005
Journal: Hepatology
Title: Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice.
Volume: 41
Issue: 1
Pages: 168-76
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Publication
21826054 | J:177202
First Author: Yamazaki Y
Year: 2011
Journal: Lab Invest
Title: Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver.
Volume: 91
Issue: 11
Pages: 1624-33
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Publication
16973756 | J:118097
First Author: Zhai Y
Year: 2007
Journal: Mol Endocrinol
Title: Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.
Volume: 21
Issue: 1
Pages: 138-47
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Publication
30102401 | J:266657
First Author: Niu B
Year: 2018
Journal: Nucleic Acids Res
Title: In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets.
Volume: 46
Issue: 16
Pages: 8385-8403
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Publication
14742670 | J:128774
First Author: Saini SP
Year: 2004
Journal: Mol Pharmacol
Title: A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
Volume: 65
Issue: 2
Pages: 292-300
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Publication
15684063 | J:96504
First Author: Stedman CA
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.
Volume: 102
Issue: 6
Pages: 2063-8
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Publication
28756207 | J:255403
 
First Author: Zhao LY
Year: 2017
Journal: Biochem Pharmacol
Title: Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression.
Volume: 142
Pages: 194-203
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Publication
23291559 | J:206906
First Author: Saito K
Year: 2013
Journal: Toxicol Sci
Title: Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia.
Volume: 132
Issue: 1
Pages: 151-61
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Publication
20185760 | J:160008
First Author: Breuker C
Year: 2010
Journal: Endocrinology
Title: Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).
Volume: 151
Issue: 4
Pages: 1653-61
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Publication
18941143 | J:149091
First Author: Maglich JM
Year: 2009
Journal: J Lipid Res
Title: The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress.
Volume: 50
Issue: 3
Pages: 439-45
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Publication
22371261 | J:317628
First Author: Chen S
Year: 2012
Journal: Hepatology
Title: Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice.
Volume: 56
Issue: 2
Pages: 658-67
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18677425 | J:140975
First Author: Scheer N
Year: 2008
Journal: J Clin Invest
Title: A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.
Volume: 118
Issue: 9
Pages: 3228-39
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Publication
20403969 | J:163295
First Author: Ross J
Year: 2010
Journal: Toxicol Sci
Title: Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Volume: 116
Issue: 2
Pages: 452-66
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Publication
26612838 | J:257395
First Author: Wahlang B
Year: 2016
Journal: Toxicol Sci
Title: Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis.
Volume: 149
Issue: 2
Pages: 396-410
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Publication
24690595 | J:215352
First Author: Luisier R
Year: 2014
Journal: Toxicol Sci
Title: Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
Volume: 139
Issue: 2
Pages: 501-11
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Publication
30573465 | J:286558
First Author: Crosby M
Year: 2019
Journal: Drug Metab Dispos
Title: Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice.
Volume: 47
Issue: 3
Pages: 279-282
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Publication
34971590 | J:321665
 
First Author: Skoda J
Year: 2022
Journal: Biochem Pharmacol
Title: Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.
Volume: 197
Pages: 114905
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Publication
21628639 | J:231430
First Author: Hasegawa M
Year: 2011
Journal: Mol Pharmacol
Title: Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.
Volume: 80
Issue: 3
Pages: 518-28
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Publication
26363009 | J:226785
First Author: MacLeod AK
Year: 2015
Journal: Cancer Res
Title: Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.
Volume: 75
Issue: 21
Pages: 4573-81
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Publication
24863967 | J:213198
First Author: Braeuning A
Year: 2014
Journal: Toxicol Sci
Title: Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.
Volume: 140
Issue: 2
Pages: 259-70
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Publication
28181583 | J:275259
 
First Author: Martinot E
Year: 2017
Journal: Sci Rep
Title: Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.
Volume: 7
Pages: 42182
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21220114 | J:245364
First Author: Wright E
Year: 2011
Journal: Structure
Title: Helix 11 dynamics is critical for constitutive androstane receptor activity.
Volume: 19
Issue: 1
Pages: 37-44
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11005856 | J:64736
First Author: Handschin C
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Volume: 97
Issue: 20
Pages: 10769-74
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12948398 | J:86933
First Author: Mäkinen J
Year: 2003
Journal: Biochem J
Title: Dual action of oestrogens on the mouse constitutive androstane receptor.
Volume: 376
Issue: Pt 2
Pages: 465-72
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15358766 | J:94993
First Author: Zhang J
Year: 2004
Journal: J Biol Chem
Title: The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.
Volume: 279
Issue: 47
Pages: 49517-22
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Publication
15591315 | J:97052
First Author: Xia J
Year: 2005
Journal: J Biol Chem
Title: Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation.
Volume: 280
Issue: 8
Pages: 7285-93
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Publication
15905360 | J:100396
First Author: Lempiäinen H
Year: 2005
Journal: Mol Endocrinol
Title: Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.
Volume: 19
Issue: 9
Pages: 2258-72
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Publication
27113289 | J:250630
First Author: Cui JY
Year: 2016
Journal: Biochim Biophys Acta
Title: RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.
Volume: 1859
Issue: 9
Pages: 1198-217
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Publication
32193417 | J:299906
First Author: Yi M
Year: 2020
Journal: Sci Rep
Title: Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.
Volume: 10
Issue: 1
Pages: 5001
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Publication
28580885 | J:317533
First Author: Kuwata K
Year: 2017
Journal: Toxicol Pathol
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