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Search results 301 to 363 out of 363 for Tmc1

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Type Details Score
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33168709 | J:300046
First Author: Yu X
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Deafness mutation D572N of TMC1 destabilizes TMC1 expression by disrupting LHFPL5 binding.
Volume: 117
Issue: 47
Pages: 29894-29903
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Allele
Tmc1<em2Ftpl> | MGI:6715680
 
Name: transmembrane channel-like gene family 1; endonuclease-mediated mutation 2, Robert Fettiplace
Allele Type: Endonuclease-mediated
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Allele
Tmc1<em5Ftpl> | MGI:7579138
 
Name: transmembrane channel-like gene family 1; endonuclease-mediated mutation 5, Robert Fettiplace
Allele Type: Endonuclease-mediated
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Allele
Tmc1<em1Ftpl> | MGI:6715678
Name: transmembrane channel-like gene family 1; endonuclease-mediated mutation 1, Robert Fettiplace
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Tmc1<em4Ftpl> | MGI:6715684
 
Name: transmembrane channel-like gene family 1; endonuclease-mediated mutation 4, Robert Fettiplace
Allele Type: Endonuclease-mediated
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Allele
Tmc1m1<C3HeB/FeJ> | MGI:3663112
 
Name: Tmc1 modifier 1; C3HeB/FeJ
Allele Type: QTL
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Allele
Tmc1m1<C57BL/6J> | MGI:3663113
 
Name: Tmc1 modifier 1; C57BL/6J
Allele Type: QTL
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Allele
Tmc1m3<DBA/2J> | MGI:3663120
 
Name: Tmc1 modifier 3; DBA/2J
Allele Type: QTL
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Allele
Tmc1m3<C3HeB/FeJ> | MGI:3663119
 
Name: Tmc1 modifier 3; C3HeB/FeJ
Allele Type: QTL
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Allele
Tmc1m2<C3HeB/FeJ> | MGI:3663114
 
Name: Tmc1 modifier 2; C3HeB/FeJ
Allele Type: QTL
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Allele
Tmc1m2<DBA/2J> | MGI:3663115
 
Name: Tmc1 modifier 2; DBA/2J
Allele Type: QTL
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Allele
Tmc1m4<C3HeB/FeJ> | MGI:3663121
 
Name: Tmc1 modifier 4; C3HeB/FeJ
Allele Type: QTL
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Allele
Tmc1m4<DBA/2J> | MGI:3663122
 
Name: Tmc1 modifier 4; DBA/2J
Allele Type: QTL
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Allele
Tmc1<em3Ftpl> | MGI:6715683
 
Name: transmembrane channel-like gene family 1; endonuclease-mediated mutation 3, Robert Fettiplace
Allele Type: Endonuclease-mediated
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Allele
Tmc1<dn> | MGI:1856845
 
Name: transmembrane channel-like gene family 1; deafness
Allele Type: Spontaneous
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Allele
Tmc1<Mhdabth> | MGI:2177263
 
Name: transmembrane channel-like gene family 1; Martin Hrabe de Angelis beethoven
Allele Type: Chemically induced (ENU)
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Allele
Tmc1<stitch> | MGI:5314996
 
Name: transmembrane channel-like gene family 1; stitch
Allele Type: Chemically induced (ENU)
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Allele
Tmc1<baringo> | MGI:5314997
 
Name: transmembrane channel-like gene family 1; baringo
Allele Type: Chemically induced (ENU)
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Allele
Tmc1<nice> | MGI:5314995
 
Name: transmembrane channel-like gene family 1; nice
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Tmc1/Tmc1<+> Tmc1m1/?
Background: involves: C3HeB/FeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1<+> Tmc1m2/?
Background: involves: C3HeB/FeJ * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1<+> Tmc1m3/?
Background: involves: C3HeB/FeJ * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1<+> Tmc1m4/?
Background: involves: C3HeB/FeJ * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110520 | autosomal recessive nonsyndromic deafness 7
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DO Term
DOID:0110563 | autosomal dominant nonsyndromic deafness 36
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Genotype
Genotype
Symbol: Tmc1/Tmc1<+>
Background: C3HeB/FeJ-Tmc1/Ieg
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1
Background: STOCK Grhl3/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tmc1/Tmc1
Background: involves: STOCK Grhl3 * M. m. molossinus
Zygosity: hm
Has Mutant Allele: true
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Publication
36917610 | J:340982
First Author: Qiu X
Year: 2023
Journal: Cell Rep
Title: The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells.
Volume: 42
Issue: 3
Pages: 112245
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Publication
16799054 | J:112247
First Author: Haywood-Watson RJ 2nd
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.
Volume: 47
Issue: 7
Pages: 3074-84
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Publication
24940003 | J:244761
First Author: Pepermans E
Year: 2014
Journal: EMBO Mol Med
Title: The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.
Volume: 6
Issue: 7
Pages: 984-92
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Publication
15537665 | J:95655
First Author: Zheng QY
Year: 2005
Journal: Hum Mol Genet
Title: Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.
Volume: 14
Issue: 1
Pages: 103-11
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Publication
15811708 | J:97048
First Author: Washington JL 3rd
Year: 2005
Journal: Hear Res
Title: Characterization of a new allele of Ames waltzer generated by ENU mutagenesis.
Volume: 202
Issue: 1-2
Pages: 161-9
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Protein Domain
IPR030718 | Protocadherin-15
Type: Family
Description: Protocadherin-15 (Pcdh15) belongs to the epsilon subfamily of nonclustered protocadherins. It is a component of the tip-links, the extracellular filaments that connect the tips of stereocilia and gate hair cell mechano-electrical transduction channels in the inner ear []. Pcdh15 interacts with transmembrane channel-like proteins TMC1 and TMC2, which have been implicated in mechanotransduction in mammalian hair cells []. Mutations in genes coding for Pcdh15 cause deafness in both mice and humans [, ]. Pcdh15 plays an important role in hair-bundle morphogenesis [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Publication
32493795 | J:300619
 
First Author: Yeh WH
Year: 2020
Journal: Sci Transl Med
Title: In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.
Volume: 12
Issue: 546
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Publication
33229591 | J:299224
First Author: Boucher S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.
Volume: 117
Issue: 49
Pages: 31278-31289
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Publication
38440182 | J:345888
 
First Author: An Y
Year: 2024
Journal: Front Pharmacol
Title: The transmembrane channel-like 6 (TMC6) in primary sensory neurons involving thermal sensation via modulating M channels.
Volume: 15
Pages: 1330167
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Publication
26092689 | J:227315
First Author: Johnson KR
Year: 2015
Journal: Mamm Genome
Title: A QTL on Chr 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice.
Volume: 26
Issue: 7-8
Pages: 338-47
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Publication
29069081 | J:248825
First Author: Mahendrasingam S
Year: 2017
Journal: PLoS One
Title: Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.
Volume: 12
Issue: 10
Pages: e0185285
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Protein
Q99PJ1
Organism: Mus musculus/domesticus
Length: 1943  
Fragment?: false
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Protein
A0A0A6YY17
Organism: Mus musculus/domesticus
Length: 1783  
Fragment?: false
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Protein
E9Q159
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
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Protein
A0A0A6YWL3
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: true
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Protein
A0A0A6YXB5
Organism: Mus musculus/domesticus
Length: 1714  
Fragment?: false
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Protein
A0A140T8S2
Organism: Mus musculus/domesticus
Length: 1675  
Fragment?: false
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Publication
21173574 | -
First Author: Kim SY
Year: 2011
Journal: Cell Adh Migr
Title: Non-clustered protocadherin.
Volume: 5
Issue: 2
Pages: 97-105
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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