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Search results 301 to 357 out of 357 for Hfe

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0.023s

Type

Details

Score

Allele

Hfe<tm2Sly> | MGI:3033459

Name:	homeostatic iron regulator; targeted mutation 2, William S Sly
Allele Type:	Targeted
Attribute String:	Humanized sequence

•

Allele

Hfe<tm1.1Gfn> | MGI:4821356

Name:	homeostatic iron regulator; targeted mutation 1.1, Susan Gilfillan
Allele Type:	Targeted
Attribute String:	Null/knockout

•

Allele

Hfe<tm1.1Nca> | MGI:2385350

Name:	homeostatic iron regulator; targeted mutation 1.1, Nancy C Andrews
Allele Type:	Targeted
Attribute String:	Humanized sequence, Hypomorph

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129S6/SvEvTac
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	Not Specified
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129S6/SvEvTac * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129S6/SvEvTac * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129S6/SvEvTac
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	Not Specified
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129X1/SvJ * C57BL/6J
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129X1/SvJ * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129X1/SvJ * C57BL/6J
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129X1/SvJ * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129P2/OlaHsd * C57BL/6
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe Tg(Vil1-cre)997Gum/?
Background:	involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	involves: 129P2/OlaHsd * C57BL/6
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe
Background:	B6.129P2-Hfe
Zygosity:	hm
Has Mutant Allele:	true

•

DO Term

DOID:0111029 | hemochromatosis type 1

•

Allele

Tg(Ttr-Hfe)1Nca | MGI:3778909

Name:	transgene insertion 1, Nancy C Andrews
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

•

HT Experiment

E-GEOD-7357 | Transcription profiling of Hfe-deficient liver and duodenum in mouse strains with differing susceptibilities to iron loading

Series Id:	GSE7357
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Strain

MGI:4453185 | C57BL/6J-Tg(Ttr-Hfe)1Nca/Mmnc

Attribute String:

transgenic, mutant strain, coisogenic

•

GO Term

GO:1990712 | HFE-transferrin receptor complex

•

Allele

Tfrc<tm2Nca> | MGI:3778906

Name:	transferrin receptor; targeted mutation 2, Nancy C Andrews
Allele Type:	Targeted

•

Publication

17945001 | -

First Author:	Coppin H
Year:	2007
Journal:	Genome Biol
Title:	Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers.
Volume:	8
Issue:	10
Pages:	R221

•

Strain

MGI:4453181 | 129S-Tfrc<tm2Nca>/Mmnc

Attribute String:

coisogenic, mutant strain, targeted mutation

•

Genotype

Symbol:	Tfrc/Tfrc
Background:	involves: 129S4/SvJae * FVB/N
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Hfe/Hfe Tg(Ttr-Hfe)1Nca/?
Background:	involves: 129S6/SvEvTac * C57BL/6
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

16604073 | J:109016

First Author:	Babitt JL
Year:	2006
Journal:	Nat Genet
Title:	Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.
Volume:	38
Issue:	5
Pages:	531-9

•

Publication

14647275 | -

First Author:	Papanikolaou G
Year:	2004
Journal:	Nat Genet
Title:	Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.
Volume:	36
Issue:	1
Pages:	77-82

•

Publication

22728873 | -

First Author:	D'Alessio F
Year:	2012
Journal:	J Hepatol
Title:	The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
Volume:	57
Issue:	5
Pages:	1052-60

•

Protein Domain

IPR033606 | Hemojuvelin

Type:

Family

Description:

Hemojuvelin, also called repulsive guidance molecule C or Hfe2, is a GPI-linked membrane protein essential for iron homeostasis []. Hemojuvelin is a bone morphogenetic protein (BMP) coreceptor; it regulates iron homeostasis by interacting with BMP ligands to induce hepcidin expression []. It forms a membrane-associated protein complex with HFE and the transferrin receptor 2 for hepcidin regulation [].

•

Gene

650 | BMP2

Type:	gene
Organism:	human

•

Publication

10047540 | J:53145

First Author:	Braud VM
Year:	1999
Journal:	Curr Opin Immunol
Title:	Functions of nonclassical MHC and non-MHC-encoded class I molecules.
Volume:	11
Issue:	1
Pages:	100-8

•

Publication

- | J:46866

First Author:	Levy JE
Year:	1998
Journal:	MGI Direct Data Submission
Title:	The Transferrin Receptor (Trfr) maps to mouse Chromosome 16

•

Publication

11447267 | J:70464

First Author:	Nicolas G
Year:	2001
Journal:	Proc Natl Acad Sci U S A
Title:	Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice.
Volume:	98
Issue:	15
Pages:	8780-5

•

Publication

9780177 | J:50232

First Author:	Riegert P
Year:	1998
Journal:	J Immunol
Title:	Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.
Volume:	161
Issue:	8
Pages:	4066-77

•

Publication

17065470 | J:123093

First Author:	Dunaief JL
Year:	2006
Journal:	Invest Ophthalmol Vis Sci
Title:	Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.
Volume:	47
Issue:	11
Pages:	4660-4

•

Publication

21292994 | J:171145

First Author:	McDonald CJ
Year:	2011
Journal:	Am J Physiol Gastrointest Liver Physiol
Title:	Iron loading and oxidative stress in the Atm-/- mouse liver.
Volume:	300
Issue:	4
Pages:	G554-60

•

Publication

11106561 | J:66131

First Author:	Santos MM
Year:	2000
Journal:	Am J Pathol
Title:	Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1.
Volume:	157
Issue:	6
Pages:	1883-92

•

Publication

11309500 | J:68985

First Author:	Sproule TJ
Year:	2001
Journal:	Proc Natl Acad Sci U S A
Title:	Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice.
Volume:	98
Issue:	9
Pages:	5170-4

•

Publication

12134060 | J:78360

First Author:	Fleming RE
Year:	2002
Journal:	Proc Natl Acad Sci U S A
Title:	Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis.
Volume:	99
Issue:	16
Pages:	10653-8

•

Publication

15951546 | J:114330

First Author:	Wallace DF
Year:	2005
Journal:	Gut
Title:	First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.
Volume:	54
Issue:	7
Pages:	980-6

•

Publication

8781118 | J:35547

First Author:	Giffon T
Year:	1996
Journal:	Immunogenetics
Title:	Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region.
Volume:	44
Issue:	5
Pages:	331-9

•

Publication

12547217 | J:108469

First Author:	Meyer PN
Year:	2002
Journal:	Blood Cells Mol Dis
Title:	Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?
Volume:	29
Issue:	3
Pages:	274-85

•

Publication

32766721 | J:305757

First Author:	Rishi G
Year:	2020
Journal:	Biosci Rep
Title:	Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.
Volume:	40
Issue:	8

•

Protein

Q7TQ32

Organism:	Mus musculus/domesticus
Length:	420
Fragment?:	false

•

Protein Coding Gene

MGI:1916835 | Hjv

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:1354956 | Tfr2

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

23874600 | J:204407

First Author:	Josson S
Year:	2013
Journal:	PLoS One
Title:	Inhibition of β2-microglobulin/hemochromatosis enhances radiation sensitivity by induction of iron overload in prostate cancer cells.
Volume:	8
Issue:	7
Pages:	e68366

•

Publication

31800957 | J:335613

First Author:	Wang CY
Year:	2020
Journal:	Blood
Title:	Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.
Volume:	135
Issue:	6
Pages:	453-456

•

Publication

9531620 | J:47457

First Author:	Santos M
Year:	1998
Journal:	Blood
Title:	Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice.
Volume:	91
Issue:	8
Pages:	3059-65

•

Publication

21943374 | J:179221

First Author:	Gnana-Prakasam JP
Year:	2012
Journal:	Biochem J
Title:	Iron-mediated retinal degeneration in haemojuvelin-knockout mice.
Volume:	441
Issue:	2
Pages:	599-608

•

Publication

24121729 | J:237471

First Author:	Delaby C
Year:	2013
Journal:	Mamm Genome
Title:	Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice.
Volume:	24
Issue:	11-12
Pages:	427-38

•

Protein Coding Gene

MGI:98821 | Trf

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

9642100 | J:51452

First Author:	Lee PL
Year:	1998
Journal:	Blood Cells Mol Dis
Title:	The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms.
Volume:	24
Issue:	2
Pages:	199-215

•

Protein Coding Gene

MGI:98822 | Tfrc

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:88127 | B2m

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

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