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Search results 101 to 200 out of 211 for Fermt3

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:3690856
Assay Type: RT-PCR
Annotation Date: 2006-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:3691190
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 12
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692441
Age: postnatal adult
Image: JAX_1305960
Specimen Label: JAX_1305960
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:3690859
Assay Type: RNA in situ
Annotation Date: 2006-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3690904
Age: embryonic day 15.0
Specimen Label: 4H
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
 
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4824828
Age: embryonic day 14.5
Image: euxassay_002482_13
Specimen Label: euxassay_002482_13
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4824828
Age: embryonic day 14.5
Image: euxassay_002482_14
Specimen Label: euxassay_002482_14
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4824828
Age: embryonic day 14.5
Image: euxassay_002482_15
Specimen Label: euxassay_002482_15
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4824828
Age: embryonic day 14.5
Image: euxassay_002482_16
Specimen Label: euxassay_002482_16
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
 
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4824828
Age: embryonic day 14.5
Image: euxassay_002482_17
Specimen Label: euxassay_002482_17
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
 
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4824828
Age: embryonic day 14.5
Image: euxassay_002482_18
Specimen Label: euxassay_002482_18
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:3690859
Assay Type: RNA in situ
Annotation Date: 2006-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:3690904
Age: embryonic day 12.0
Note: Expression was particularly strong in large multinucleated cells, most likely representing megakaryocytes.
Specimen Label: 4B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3690859
Assay Type: RNA in situ
Annotation Date: 2006-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Pattern: Non-Uniform
Stage: TS21
Assay Id: MGI:3690904
Age: embryonic day 13.0
Note: Expression was particularly strong in large multinucleated cells, most likely representing megakaryocytes.
Specimen Label: 4D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3690859
Assay Type: RNA in situ
Annotation Date: 2006-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Non-Uniform
Stage: TS23
Assay Id: MGI:3690904
Age: embryonic day 15.0
Note: Expression was particularly strong in large multinucleated cells, most likely representing megakaryocytes.
Specimen Label: 4F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3690865
Assay Type: Immunohistochemistry
Annotation Date: 2006-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:3690912
Age: embryonic day 14.5
Note: Expression was detected in the liver with particularly high signals in megakaryocytes.
Specimen Label: 5E, 5E'
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692441
Age: postnatal adult
Image: JAX_1305961
Specimen Label: JAX_1305961
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
   
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2024-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7576142
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2024-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7576142
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1803007
Assay Type: RNA in situ
Annotation Date: 2024-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7576142
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692441
Age: postnatal adult
Image: JAX_1305959
Specimen Label: JAX_1305959
Detected: true
Specimen Num: 1
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Publication
9826666 | J:51223
First Author: Spinelli SL
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli.
Volume: 95
Issue: 24
Pages: 14136-41
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Publication
31477636 | J:295224
First Author: Yan Y
Year: 2019
Journal: Aging (Albany NY)
Title: Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice.
Volume: 11
Issue: 17
Pages: 6951-6959
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Publication
19265824 | J:146753
First Author: Hidalgo A
Year: 2009
Journal: Nat Med
Title: When integrins fail to integrate.
Volume: 15
Issue: 3
Pages: 249-50
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Publication
29141864 | J:253408
First Author: Shiratori T
Year: 2018
Journal: J Immunol
Title: IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1.
Volume: 200
Issue: 1
Pages: 218-228
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Publication
16876785 | J:114381
First Author: Ussar S
Year: 2006
Journal: Exp Cell Res
Title: The Kindlins: subcellular localization and expression during murine development.
Volume: 312
Issue: 16
Pages: 3142-51
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Publication
19234461 | J:146783
First Author: Moser M
Year: 2009
Journal: Nat Med
Title: Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.
Volume: 15
Issue: 3
Pages: 300-5
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Publication
24004668 | J:203825
First Author: Petzold T
Year: 2013
Journal: Blood
Title: β1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse.
Volume: 122
Issue: 15
Pages: 2723-31
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Publication
34888947 | J:325644
First Author: Härzschel A
Year: 2022
Journal: J Leukoc Biol
Title: Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
Volume: 111
Issue: 4
Pages: 745-758
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Publication
30783087 | J:275029
First Author: Guo L
Year: 2019
Journal: Nat Commun
Title: Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Volume: 10
Issue: 1
Pages: 845
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Publication
31537712 | J:280278
First Author: Klapproth S
Year: 2019
Journal: J Cell Biol
Title: A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
Volume: 218
Issue: 10
Pages: 3436-3454
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Publication
32386455 | J:298115
First Author: Marcovecchio PM
Year: 2020
Journal: J Leukoc Biol
Title: Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance.
Volume: 107
Issue: 6
Pages: 883-892
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Publication
18662549 | J:145476
First Author: Krüger M
Year: 2008
Journal: Cell
Title: SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function.
Volume: 134
Issue: 2
Pages: 353-64
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Publication
26438512 | J:229952
First Author: Klapproth S
Year: 2015
Journal: Blood
Title: Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice.
Volume: 126
Issue: 24
Pages: 2592-600
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Publication
28157452 | J:260512
First Author: Wilson ZS
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Activated β2 Integrins Restrict Neutrophil Recruitment during Murine Acute Pseudomonal Pneumonia.
Volume: 56
Issue: 5
Pages: 620-627
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Publication
35354953 | J:327497
First Author: Fischer A
Year: 2022
Journal: Nat Immunol
Title: Neutrophils direct preexisting matrix to initiate repair in damaged tissues.
Volume: 23
Issue: 4
Pages: 518-531
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Publication
24969775 | J:227094
First Author: Xu Z
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.
Volume: 34
Issue: 9
Pages: 1961-7
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Publication
23144497 | J:190864
First Author: Dixit N
Year: 2012
Journal: J Immunol
Title: Leukocyte function antigen-1, kindlin-3, and calcium flux orchestrate neutrophil recruitment during inflammation.
Volume: 189
Issue: 12
Pages: 5954-64
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Publication
18278053 | J:133659
First Author: Moser M
Year: 2008
Journal: Nat Med
Title: Kindlin-3 is essential for integrin activation and platelet aggregation.
Volume: 14
Issue: 3
Pages: 325-30
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Publication
30187863 | J:277471
   
First Author: Moretti FA
Year: 2018
Journal: Elife
Title: Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
Volume: 7
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Publication
31481482 | J:282588
First Author: Marx C
Year: 2019
Journal: Blood
Title: Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps.
Volume: 134
Issue: 21
Pages: 1859-1872
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Publication
24523237 | J:210761
First Author: Kasirer-Friede A
Year: 2014
Journal: Blood
Title: ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.
Volume: 123
Issue: 20
Pages: 3156-65
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Publication
20110424 | J:160267
First Author: Uhrin P
Year: 2010
Journal: Blood
Title: Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.
Volume: 115
Issue: 19
Pages: 3997-4005
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Publication
21357746 | J:170685
First Author: Schmidt S
Year: 2011
Journal: J Cell Biol
Title: Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption.
Volume: 192
Issue: 5
Pages: 883-97
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Publication
37267105 | J:338516
First Author: Kamioka Y
Year: 2023
Journal: Cell Rep
Title: Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
Volume: 42
Issue: 6
Pages: 112580
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Publication
26151572 | J:224370
 
First Author: Wu C
Year: 2015
Journal: Nat Commun
Title: Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis.
Volume: 6
Pages: 7531
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Publication
21308776 | J:233118
First Author: Abdallah BM
Year: 2011
Journal: J Bone Miner Res
Title: DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Volume: 26
Issue: 7
Pages: 1457-71
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Fermt3<em2Smoc> | MGI:7289670
Name: fermitin family member 3; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Rasgrp2<tm1Amg> | MGI:3055135
Name: RAS, guanyl releasing protein 2; targeted mutation 1, Ann M Graybiel
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fermt3<tm1Ref> | MGI:3785479
Name: fermitin family member 3; targeted mutation 1, Reinhard Fassler
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Protein Coding Gene
MGI:1333849 | Rasgrp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Rasgrp2/Rasgrp2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fermt3/Fermt3
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110912 | leukocyte adhesion deficiency 3
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Allele
Fermt3<em1Smoc> | MGI:7263276
Name: fermitin family member 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Itgb2<tm1.1Arte> | MGI:5524988
 
Name: integrin beta 2; targeted mutation 1.1, TaconicArtemis
Allele Type: Targeted
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Strain
MGI:6770753 | C57BL/6-Fermt3<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
25918984 | J:226007
First Author: Savinko TS
Year: 2015
Journal: J Invest Dermatol
Title: Functional Beta2-Integrins Restrict Skin Inflammation In Vivo.
Volume: 135
Issue: 9
Pages: 2249-2257
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Publication
26405763 | J:243329
First Author: Meakin PJ
Year: 2015
Journal: PLoS One
Title: Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation.
Volume: 10
Issue: 9
Pages: e0138872
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Genotype
Genotype
Symbol: Itgb2/Itgb2
Background: involves: C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
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Publication
12697302 | -
First Author: Weinstein EJ
Year: 2003
Journal: Biochim Biophys Acta
Title: URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.
Volume: 1637
Issue: 3
Pages: 207-16
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Publication
22030399 | -
First Author: Liu J
Year: 2011
Journal: J Biol Chem
Title: Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.
Volume: 286
Issue: 50
Pages: 43334-42
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Publication
25173804 | -
 
First Author: Rozario T
Year: 2014
Journal: Mech Dev
Title: Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis.
Volume: 133
Pages: 203-17
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Publication
21761481 | -
First Author: Canning CA
Year: 2011
Journal: Dev Dyn
Title: Developmental expression of the fermitin/kindlin gene family in Xenopus laevis embryos.
Volume: 240
Issue: 8
Pages: 1958-63
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Publication
24477625 | -
First Author: Ye F
Year: 2014
Journal: Front Med
Title: Talin and kindlin: the one-two punch in integrin activation.
Volume: 8
Issue: 1
Pages: 6-16
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Protein
A0A494BBJ8
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
A0A494B9F7
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
A0A2I3BPQ7
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein
A6X940
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein Domain
IPR037837 | PH_Kindlin/fermitin
Type: Domain
Description: Fermitin, also known as Unc-112-related protein [], functions as a mediator of integrin inside-out signalling. The recruitment of Fermitin proteins and Talin to the membrane mediates the terminal event of integrin signalling, via interaction with integrin beta subunits []. Fermatin has a FERM domain interrupted with a pleckstrin homology (PH) domain []. Fermitin family homologues (Fermt1, 2, and 3, also known as Kindlins) are each encoded by a different gene. In mammalian studies, Fermt1 is generally expressed in epithelial cells, Fermt2 is expressed in muscle tissues, and Fermt3 is expressed in hematopoietic lineages. Specifically Fermt2 is expressed in smooth and striated muscle tissues in mice and in the somites (a trunk muscle precursor) and neural crest in Xenopus embryos. As such it has been proposed that Fermt2 plays a role in cardiomyocyte and neural crest differentiation. Expression of mammalian Fermt3 is associated with hematopoietic lineages: the anterior ventral blood islands, vitelline veins, and early myeloid cells. In Xenopus embryos this expression, also include the notochord and cement gland [, ].This entry represents the PH domain of fermitins.
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