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Search results 201 to 223 out of 223 for Fmo3

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0.018s

Type

Details

Score

Publication

8654418 | -

First Author:	Dolphin CT
Year:	1996
Journal:	Eur J Biochem
Title:	Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04.
Volume:	235
Issue:	3
Pages:	683-9

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Publication

8188717 | -

First Author:	Burnett VL
Year:	1994
Journal:	J Biol Chem
Title:	Cloning and sequencing of flavin-containing monooxygenases FMO3 and FMO4 from rabbit and characterization of FMO3.
Volume:	269
Issue:	19
Pages:	14314-22

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Publication

18930751 | -

First Author:	Henderson MC
Year:	2008
Journal:	Toxicol Appl Pharmacol
Title:	Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes.
Volume:	233
Issue:	3
Pages:	420-7

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GO Term

GO:0004499 | N,N-dimethylaniline monooxygenase activity

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Publication

9536088 | -

First Author:	Treacy EP
Year:	1998
Journal:	Hum Mol Genet
Title:	Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.
Volume:	7
Issue:	5
Pages:	839-45

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Protein Domain

IPR002255 | Flavin_mOase_3

Type:

Family

Description:

Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes []. Using an NADPH cofactor and FAD prosthetic group,these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen,sulphur, phosphorous and selenium atoms in a range of structurally diversecompounds. Five mammalian forms of FMO are now known and have been designatedFMO1-FMO5 [, , , , ].The mRNA encoding FMO3 is abundant in adult liver and is also present, inlow abundance, in some foetal tissues. Thus, like FMO1, FMO3 is subjectto developmental and tissue-specific regulation, with a developmental switchin the expression of the genes taking place in the liver []. The deduced amino acid sequence of human FM03 includes the putative FAD-(GxGxxG) and NADP+pyrophosphate-binding (GxGxxA) sites characteristic ofmammalian FMOs [], a 'FATGY' motif that has also been observed in a rangeof siderphore biosynthetic enzymes [], and a C-terminal hydrophobic segment that is believed to anchor the monooxygenase to the microsomal membrane [].Mutations in human FMO3 impair N-oxygenation of xenobiotics and are responsible for the trimethylaminuria phenotype []. Three disease-causingmutations have been identified. Nonsense and missense mutations are associated with a severe phenotype and are also implicated in impairedmetabolism of other nitrogen- and sulphur-containing substrates, includingbiogenic amines, both clinically and when mutated proteins expressed fromcDNA are studied in vitro []. Human FMO3 thus plays a critical role in themetabolism of xenobiotic substrates and endogenous amines.

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Publication

25600868 | J:222809

First Author:	Warrier M
Year:	2015
Journal:	Cell Rep
Title:	The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

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Protein

P97501

Organism:	Mus musculus/domesticus
Length:	534
Fragment?:	false

•

Protein

Q3UEN4

Organism:	Mus musculus/domesticus
Length:	534
Fragment?:	false

•

Protein

J3QMN6

Organism:	Mus musculus/domesticus
Length:	532
Fragment?:	false

•

Protein

Q8C7J1

Organism:	Mus musculus/domesticus
Length:	280
Fragment?:	false

•

Publication

2355001 | -

First Author:	Ozols J
Year:	1990
Journal:	J Biol Chem
Title:	Covalent structure of liver microsomal flavin-containing monooxygenase form 1.
Volume:	265
Issue:	18
Pages:	10289-99

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Publication

9538688 | -

First Author:	Stehr M
Year:	1998
Journal:	Trends Biochem Sci
Title:	A hydrophobic sequence motif common to N-hydroxylating enzymes.
Volume:	23
Issue:	2
Pages:	56-7

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Publication

23177478 | J:197486

First Author:	Li Q
Year:	2013
Journal:	Curr Biol
Title:	Synchronous evolution of an odor biosynthesis pathway and behavioral response.
Volume:	23
Issue:	1
Pages:	11-20

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Publication

23846873 | J:312084

First Author:	Lee C
Year:	2013
Journal:	Drug Metab Dispos
Title:	Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.
Volume:	41
Issue:	10
Pages:	1782-6

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Publication

33330474 | J:341883

First Author:	Gatticchi L
Year:	2020
Journal:	Front Cell Dev Biol
Title:	Tm7sf2 Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics.
Volume:	8

Pages:	592573

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Publication

9076656 | J:40884

First Author:	Itoh K
Year:	1997
Journal:	J Toxicol Sci
Title:	Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ).
Volume:	22
Issue:	1
Pages:	45-56

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Publication

1417778 | -

First Author:	Dolphin CT
Year:	1992
Journal:	Biochem J
Title:	Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.
Volume:	287 ( Pt 1)

Pages:	261-7

•

Publication

2318837 | -

First Author:	Lawton MP
Year:	1990
Journal:	J Biol Chem
Title:	The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes.
Volume:	265
Issue:	10
Pages:	5855-61

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Publication

1712018 | -

First Author:	Dolphin C
Year:	1991
Journal:	J Biol Chem
Title:	Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).
Volume:	266
Issue:	19
Pages:	12379-85

•

Publication

8486656 | -

First Author:	Atta-Asafo-Adjei E
Year:	1993
Journal:	J Biol Chem
Title:	Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase 1C1. Evidence for a third gene subfamily in rabbits.
Volume:	268
Issue:	13
Pages:	9681-9

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Publication

1542660 | -

First Author:	Lomri N
Year:	1992
Journal:	Proc Natl Acad Sci U S A
Title:	Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.
Volume:	89
Issue:	5
Pages:	1685-9

•

Publication

28935756 | J:269250

First Author:	Trenteseaux C
Year:	2017
Journal:	Arterioscler Thromb Vasc Biol
Title:	Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids.
Volume:	37
Issue:	11
Pages:	2053-2063

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