Syndetin (VPS50) is a component of the endosome-associated recycling protein (EARP) complex. This complex and the Golgi-associated retrograde protein (GARP) complex share four of the five subunits, but EARP contains syndetin in place of the Vps54 subunit of GARP, with the effect that the EARP complex is directed to endosomes rather than the Golgi. EARP in required for membrane-fusion during endocytic recycling of receptors and is described as a tethering complex [].
This entry represents a domain found in vacuolar protein sorting-associated protein 54 (VPS54), which acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). VPS54 is required to tether the complex to the TGN. However, it is not involved in endocytic recycling [].Proteins containing this domain also includes VPS50 (also known as Syndetin), which is a component of the EARP complex that is involved in endocytic recycling. It is required to tether the EARP complex to recycling endosomes. Nevertheless, it is involved in retrograde transport from early and late endosomes to the TGN [].
