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Search results 801 to 840 out of 840 for Hspa5

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0.019s

Type

Details

Score

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

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Allele

Hspa5<em1Smoc> | MGI:7290267

Name:	heat shock protein 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Publication

2766926 | -

First Author:	Heschl MF
Year:	1989
Journal:	DNA
Title:	Characterization of the hsp70 multigene family of Caenorhabditis elegans.
Volume:	8
Issue:	4
Pages:	233-43

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Publication

2661018 | -

First Author:	Rose MD
Year:	1989
Journal:	Cell
Title:	KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene.
Volume:	57
Issue:	7
Pages:	1211-21

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Publication

20886215 | -

First Author:	Morrow MW
Year:	2011
Journal:	Curr Genet
Title:	The Candida albicans Kar2 protein is essential and functions during the translocation of proteins into the endoplasmic reticulum.
Volume:	57
Issue:	1
Pages:	25-37

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Publication

20430899 | -

First Author:	Hale SJ
Year:	2010
Journal:	J Biol Chem
Title:	Interactions between Kar2p and its nucleotide exchange factors Sil1p and Lhs1p are mechanistically distinct.
Volume:	285
Issue:	28
Pages:	21600-6

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Publication

30563838 | -

First Author:	Pobre KFR
Year:	2019
Journal:	J Biol Chem
Title:	The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends.
Volume:	294
Issue:	6
Pages:	2098-2108

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Publication

18285827 | -

First Author:	Anttonen AK
Year:	2008
Journal:	Eur J Hum Genet
Title:	Novel SIL1 mutations and exclusion of functional candidate genes in Marinesco-Sjögren syndrome.
Volume:	16
Issue:	8
Pages:	961-9

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Protein Domain

IPR042050 | BIP_NBD

Type:

Domain

Description:

This entry includes human endoplasmic reticulum chaperone BIP (also known as 70kDa heat shock protein 5, HSPA5, glucose-regulated protein 78/GRP78, and immunoglobulin heavy chain-binding protein), yeast Kar2p (also known as Grp78p) [, ], hsp-3 from C. elegans []and related proteins. BIP/HSPA5 belongs to the heat shock protein 70 (HSP70) family of chaperones that assist in protein folding and assembly and can direct incompetent 'client' proteins towards degradation. HSPA5 and Kar2p are chaperones of the endoplasmic reticulum (ER). Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Multiple ER DNAJ domain proteins have been identified and may exist in distinct complexes with HSPA5 in various locations in the ER, for example DNAJC3-p58IPK in the lumen []. HSPA5-NEFs include SIL1, whose disruption causes the Marinesco-Sjogren syndrome, and an atypical HSP70 family protein HYOU1/ORP150 [, ]. The ATPase activity of Kar2p is stimulated by the NEFs: Sil1p and Lhs1p [].

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Publication

37421621 | J:338470

First Author:	Mun SH
Year:	2023
Journal:	Cell Rep
Title:	Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
Volume:	42
Issue:	7
Pages:	112746

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Publication

31492921 | J:284061

First Author:	Bensellam M
Year:	2019
Journal:	Sci Rep
Title:	Phlda3 regulates beta cell survival during stress.
Volume:	9
Issue:	1
Pages:	12827

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Publication

22128176 | J:181385

First Author:	Jurczak MJ
Year:	2012
Journal:	J Biol Chem
Title:	Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.
Volume:	287
Issue:	4
Pages:	2558-67

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Publication

22083493 | J:320710

First Author:	Ciocca DR
Year:	2012
Journal:	Histochem Cell Biol
Title:	Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression.
Volume:	137
Issue:	2
Pages:	187-94

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Publication

36322628 | J:335296

First Author:	Zhang Y
Year:	2022
Journal:	Sci Transl Med
Title:	Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis.
Volume:	14
Issue:	669
Pages:	eabo1981

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Publication

25545477 | J:219198

First Author:	Luo H
Year:	2015
Journal:	Lab Invest
Title:	Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.
Volume:	95
Issue:	3
Pages:	320-33

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Publication

36233305 | J:330157

First Author:	Hyde LF
Year:	2022
Journal:	Int J Mol Sci
Title:	A Dpagt1 Missense Variant Causes Degenerative Retinopathy without Myasthenic Syndrome in Mice.
Volume:	23
Issue:	19

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Publication

30045879 | J:300042

First Author:	Hegyi E
Year:	2019
Journal:	Gut
Title:	Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice.
Volume:	68
Issue:	2
Pages:	301-312

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Publication

32116022 | J:300037

First Author:	Orekhova A
Year:	2020
Journal:	Am J Physiol Gastrointest Liver Physiol
Title:	Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice.
Volume:	318
Issue:	4
Pages:	G694-G704

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Publication

25926690 | J:222774

First Author:	Alam SM
Year:	2015
Journal:	Reproduction
Title:	Identification of target genes for a prolactin family paralog in mouse decidua.
Volume:	149
Issue:	6
Pages:	625-32

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Publication

37807968 | J:342349

First Author:	Gurri S
Year:	2023
Journal:	EMBO Mol Med
Title:	NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.
Volume:	15
Issue:	11
Pages:	e17761

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Publication

34185677 | J:309416

First Author:	Enriquez C
Year:	2021
Journal:	Cancer Res
Title:	Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.
Volume:	81
Issue:	16
Pages:	4257-4274

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Publication

23108377 | J:191742

First Author:	Baird M
Year:	2013
Journal:	Lab Invest
Title:	The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner.
Volume:	93
Issue:	1
Pages:	112-22

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Publication

21358806 | J:171086

First Author:	Audouard C
Year:	2011
Journal:	PLoS One
Title:	Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes.
Volume:	6
Issue:	2
Pages:	e17109

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Publication

22581041 | J:186441

First Author:	Sims-Robinson C
Year:	2012
Journal:	Diabetologia
Title:	Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes.
Volume:	55
Issue:	8
Pages:	2276-84

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Publication

17268797 | J:119770

First Author:	Laybutt DR
Year:	2007
Journal:	Diabetologia
Title:	Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.
Volume:	50
Issue:	4
Pages:	752-63

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Publication

28274919 | J:241580

First Author:	Mahmassani ZS
Year:	2017
Journal:	Am J Physiol Cell Physiol
Title:	α₇β₁ Integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise.
Volume:	312
Issue:	5
Pages:	C638-C650

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Publication

37983263 | J:344734

First Author:	Jani PK
Year:	2023
Journal:	PLoS Biol
Title:	The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes.
Volume:	21
Issue:	11
Pages:	e3002015

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Protein

P20029

Organism:	Mus musculus/domesticus
Length:	655
Fragment?:	false

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Protein

Q3TI47

Organism:	Mus musculus/domesticus
Length:	655
Fragment?:	false

•

Protein

Q3TKF8

Organism:	Mus musculus/domesticus
Length:	655
Fragment?:	false

•

Protein

Q3UEM8

Organism:	Mus musculus/domesticus
Length:	520
Fragment?:	true

•

Protein

Q9DC41

Organism:	Mus musculus/domesticus
Length:	655
Fragment?:	false

•

Protein

Q3TWF2

Organism:	Mus musculus/domesticus
Length:	655
Fragment?:	false

•

Protein

Q3U9G2

Organism:	Mus musculus/domesticus
Length:	655
Fragment?:	false

•

Protein

Q3U7T8

Organism:	Mus musculus/domesticus
Length:	619
Fragment?:	true

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Protein

Q3U6V3

Organism:	Mus musculus/domesticus
Length:	655
Fragment?:	false

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Publication

32673694 | J:321007

First Author:	Stengel ST
Year:	2020
Journal:	Gastroenterology
Title:	Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.
Volume:	159
Issue:	4
Pages:	1357-1374.e10

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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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