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Search results 301 to 342 out of 342 for Shc2

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Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q3URY3
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Publication
8808684 | -
First Author: Nakamura T
Year: 1996
Journal: Oncogene
Title: N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.
Volume: 13
Issue: 6
Pages: 1111-21
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Protein Domain
IPR029593 | Shc3/ShcC/N-Shc
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].Shc3 (also known as NShc from neuronal Shc) mediates neurotrophin and other neuronal signallings in the central nervous system [, ].
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Publication
17452444 | J:122785
First Author: Jones N
Year: 2007
Journal: Mol Cell Biol
Title: Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Volume: 27
Issue: 13
Pages: 4759-73
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Publication
14665640 | -
First Author: Audero E
Year: 2004
Journal: J Biol Chem
Title: Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.
Volume: 279
Issue: 13
Pages: 13224-33
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Publication
22286768 | J:191777
First Author: Ursini-Siegel J
Year: 2012
Journal: Oncogene
Title: The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.
Volume: 31
Issue: 48
Pages: 5038-44
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Publication
23695548 | J:199117
First Author: Ahn R
Year: 2013
Journal: Cancer Res
Title: The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.
Volume: 73
Issue: 14
Pages: 4521-32
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Publication
23277357 | -
First Author: Northey JJ
Year: 2013
Journal: J Biol Chem
Title: Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.
Volume: 288
Issue: 7
Pages: 5210-22
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Publication
1623525 | J:17164
First Author: Pelicci G
Year: 1992
Journal: Cell
Title: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Volume: 70
Issue: 1
Pages: 93-104
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Publication
22948967 | J:194646
First Author: Turco MY
Year: 2012
Journal: Stem Cells
Title: Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Volume: 30
Issue: 11
Pages: 2423-36
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Publication
24430869 | -
First Author: Wills MK
Year: 2014
Journal: Mol Biol Cell
Title: The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.
Volume: 25
Issue: 6
Pages: 739-52
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Publication
7544002 | -
First Author: Zhou MM
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Volume: 92
Issue: 17
Pages: 7784-8
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Protein Domain
IPR035676 | SHC_SH2
Type: Domain
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].SHC is composed of an N-terminal domain that interacts with proteins containing phosphorylated tyrosines, a (glycine/proline)-rich collagen-homology domain that contains the phosphorylated binding site, and a C-terminal SH2 domain. SH2 has been shown to interact with the tyrosine-phosphorylated receptors of EGF and PDGF and with the tyrosine-phosphorylated C chain of the T-cell receptor, providing one of the mechanisms of T-cell-mediated Ras activation []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
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Protein Domain
IPR029596 | SHC4
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].A fourth Shc family protein, ShcD/Shc4, is expressed in adult brain and skeletal muscle. ShcD can associate via its PTB domain with the phosphorylated muscle-specific kinase (MuSK) receptor tyrosine kinase and undergo tyrosine phosphorylation downstream of activated MuSK. Therefore, ShcD may mediate a specific aspect of signalling downstream of the MuSK receptor []. ShcD also interacts with EGFR receptor (epidermal growth factor receptor) and facilitates its ligand-independent phosphorylation []. ShcD has been shown to be a modulator in the transition of embryonic stem cell (ESC) to epiblast stem cells (EpiSCs), the initial step for ESCs to commit to differentiation [].
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Protein Domain
IPR029586 | Shc1/ShcA
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].Shc1 (ShcA) adaptor transduces phosphotyrosine-dependent signals downstream of receptor tyrosine kinases (RTK) and non-RTKs, which regulates signalling pathways in breast cancer cells []. Its SH2 domain is critical for tumour survival during mammary tumorigenesis [], while its PTB domain functions as a biological sensor of phosphotyrosine signalling during breast cancer progression []. Shc1 is required for transforming growth factor beta (TGF-beta)-induced breast cancer cell migration, invasion, and metastasis []. It is also involved in signalling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis [].
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Protein
Q3ZAX3
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
A0A1Y7VKQ1
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q61120
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
P98083
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Protein
Q6S5L9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
A0A5F8MPM1
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
A2AUN0
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Protein
D3Z2I8
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Protein
Q8CB26
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Protein
D3YZV5
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
D3YXZ9
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
D3Z5U6
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: true
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Publication
10398925 | -
First Author: Grucza RA
Year: 1999
Journal: Med Res Rev
Title: SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.
Volume: 19
Issue: 4
Pages: 273-93
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Publication
19273114 | -
 
First Author: Kasembeli MM
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
Volume: 14
Pages: 1010-22
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Publication
19926274 | -
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
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