| First Author | Wulczyn FG | Year | 1992 |
| Journal | Nature | Volume | 358 |
| Issue | 6387 | Pages | 597-9 |
| PubMed ID | 1501714 | Mgi Jnum | J:2096 |
| Mgi Id | MGI:50620 | Doi | 10.1038/358597a0 |
| Citation | Wulczyn FG, et al. (1992) Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature 358(6387):597-9 |
| abstractText | The NF-kappa B subunits p50 and p65 and the product of the rel proto-oncogene are members of a growing class of transcription factors with a unique DNA-binding and dimerization domain. Nuclear transfer of each of these factors is controlled by cytoplasmic inhibitors, and regulated by specific stimuli. The inhibitors I kappa B-alpha and -beta and pp40 recognize either p65 or the c-rel protein. We show here that the proto-oncogene bcl-3, believed to be involved in certain human B-cell leukaemias, encodes a protein that functions as an I kappa B-like molecule for native NF-kappa B but is specific for the p50 subunit. The ankyrin repeat domain of the bcl-3 product is shown to mediate complex formation with NF-kappa B dimers by contracting the conserved dimerization domain of NF-kappa B. |
