| Primary Identifier | MGI:894297 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12757 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable GTPase binding activity; clathrin heavy chain binding activity; and peptide binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Predicted to act upstream of or within cell division. Located in cytoplasmic vesicle and postsynaptic endocytic zone cytoplasmic component. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human CLTA (clathrin light chain A). PHENOTYPE: Homozygous null mice exhibit an enhanced isotype switch to IgA production, abnormal synaptic vesicle recycling, a reduced synaptic vesicle pool, impaired neurotransmission, and deficits in motor coordination. About 50% die within a week of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
