| First Author | Hata K | Year | 2006 |
| Journal | Cancer Lett | Volume | 239 |
| Issue | 1 | Pages | 123-8 |
| PubMed ID | 16168560 | Mgi Jnum | J:114612 |
| Mgi Id | MGI:3689492 | Doi | 10.1016/j.canlet.2005.07.033 |
| Citation | Hata K, et al. (2006) beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice. Cancer Lett 239(1):123-8 |
| abstractText | Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop in the large bowel of aged Apc(Min/+) mice. In this study, we determined the presence and location of BCAC in the large intestine of juvenile Apc(Min/+) mice (3 and 5 weeks of age). Surprisingly, BCAC were noted in the colon of even Apc(Min/+) mice of both ages, and mainly located in the distal and middle segments of the colon. Also, a few microadenomas were detected in Apc(Min/+) mice of 5-week old. Our results may indicate need of further investigation of the colorectal mucosa of Apc(Min/+) mice for examining colorectal carcinogenesis using Apc(Min/+) mice. |
