| First Author | Hedrick CC | Year | 1993 |
| Journal | J Biol Chem | Volume | 268 |
| Issue | 27 | Pages | 20676-82 |
| PubMed ID | 8376417 | Mgi Jnum | J:92454 |
| Mgi Id | MGI:3052649 | Doi | 10.1016/s0021-9258(20)80777-7 |
| Citation | Hedrick CC, et al. (1993) Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice. J Biol Chem 268(27):20676-82 |
| abstractText | The role of apolipoprotein A-II (apoA-II) in the metabolism of high density lipoproteins (HDL) is poorly understood. Previous studies of naturally occurring variations of apoA-II in mice have, however, suggested that apoA-II expression influences HDL size and concentration. We now provide definitive evidence of this using transgenic mice overexpressing mouse apoA-II. Thus, as compared with nontransgenic littermates, transgenic mice possessing 4-fold elevations of apoA-II mRNA and 2-3-fold elevations in plasma apoA-II levels exhibited more than a 2-fold increase in HDL levels as well as about a 25% increase in average HDL diameter. Overexpression of mouse apoA-II also resulted in a substantial decrease in the levels of apolipoprotein E associated with HDL, suggesting that apoA-II can displace apoE from HDL. The apoA-II transgenic mice also exhibited a 2-4-fold increase in plasma very low density and low density lipoprotein-cholesterol levels, suggesting novel interactions among the classes of plasma lipoproteins. |
