| Primary Identifier | MGI:2446700 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 240690 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cytokine-mediated signaling pathway; negative regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; eye; foregut-midgut junction; future brain; and olfactory epithelium. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor). PHENOTYPE: Myeloid-specific homozygous knockout causes hyperinflammation and results in increased susceptibility to polymicrobial sepsis, LPS-induced shock and DSS-induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
