| Primary Identifier | MGI:2684950 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 226720 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Involved in endosome to lysosome transport. Acts upstream of or within G protein-coupled receptor catabolic process; autophagy; and glucose homeostasis. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Is expressed in several structures, including liver; reproductive system; skeletal muscle; stomach; and thymus. Orthologous to human BECN2 (beclin 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic and preweaning lethality with imapired basal and starvation-induced autophagy. Mice heterozygous for this allele exhibit increased susteptibility to obesity, insulin resistance and impaired glucosetolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
