| Primary Identifier | MGI:107567 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15944 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables GTPase activity and anion binding activity. Involved in several processes, including macroautophagy; positive regulation of macroautophagy; and regulation of defense response. Acts upstream of or within cellular response to type II interferon and response to bacterium. Located in cytoplasmic vesicle and vacuole. Is active in Golgi membrane; lysosomal membrane; and mitochondrial membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). PHENOTYPE: Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
