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Protein Coding Gene : Ptk2b PTK2 protein tyrosine kinase 2 beta

Primary Identifier  MGI:104908 Organism  Mus musculus
Chromosome  14 NCBI Gene Number  19229
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1.1)

Exhibits non-membrane spanning protein tyrosine kinase activity. Predicted to contribute to NMDA glutamate receptor activity. Involved in several processes, including regulation of cell migration; regulation of intracellular signal transduction; and regulation of phosphate metabolic process. Localizes to nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and heart. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta).
PHENOTYPE: Mice homozygous for a knock-out allele show alterations in endothelial nitric oxide synthase-mediated vascular function and angiogenic responses. Mice homozygous for a second knock-out allele exhibit multiple defects in macrophage migration and function. [provided by MGI curators]
  • synonyms:
  • proline-rich tyrosine kinase 2,
  • CAKbeta,
  • MGI:2444305,
  • PTK2 protein tyrosine kinase 2 beta,
  • MGD-MRK-29062,
  • E430023O05Rik,
  • RIKEN cDNA E430023O05 gene,
  • cellular adhesion kinase beta,
  • PYK2,
  • Raftk,
  • related adhesion focal tyrosine kinase,
  • Ptk2b,
  • calcium-dependent tyrosine kinase

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

169 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications