Primary Identifier | MGI:103239 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 83383 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in cellular response to dexamethasone stimulus; negative regulation of macromolecule biosynthetic process; and protein-containing complex assembly. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human TFAP4 (transcription factor AP-4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial prenatal lethality and reduced suppression of Cd4 in double negative thymocytes. [provided by MGI curators] |