| Primary Identifier | MGI:2182061 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 252870 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in regulation of circadian rhythm; regulation of protein stability; and transcription elongation-coupled chromatin remodeling. Located in XY body; cytoplasm; and nucleus. Is expressed in blastocyst; embryo; inner cell mass; and trophectoderm. Orthologous to human USP7 (ubiquitin specific peptidase 7). PHENOTYPE: Mice homozygous for a null allele show embryonic growth arrest and die between E6.5 and E7.5. Mice homozygous for a conditional allele activated in neural cells exhibit complete neonatal lethality, absent gastric milk, uncoordinated movement and abnormalforebrain morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
