| Primary Identifier | MGI:2387123 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 240028 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables aminopeptidase activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within protein catabolic process. Located in cytoplasmic vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Is expressed in extraembryonic component; labyrinthine zone; and placenta. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human LNPEP (leucyl and cystinyl aminopeptidase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a somewhat reduced tissue uptake of glucose either basally or after insulin stimulation. Mice homozygous for a different knock-out allele exhibit impaired coordination at 3 months and impaired spatial working memory in a Y maze at 6 months of age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
