Primary Identifier | MGI:95625 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 14408 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in modulation of chemical synaptic transmission. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in brain; cerebral cortex; and retina. Orthologous to human GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1). PHENOTYPE: Mice homozygous for a knock-out allele display altered visual processing in the retina. Mice homozygous for a different knock-out allele exhibit alterations of mechanical pain sensitivity, GABA-inhibited spinal cord responses, and olfactory function. [provided by MGI curators] |