Primary Identifier | MGI:1277117 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 19244 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein tyrosine phosphatase activity. Predicted to be located in endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system and heart. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2). PHENOTYPE: Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth. Male mice show atrophied testis and low sperm count, leading to impaired reproductive ability. [provided by MGI curators] |