Primary Identifier | MGI:1891374 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 114642 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables histone reader activity and lysine-acetylated histone binding activity. Involved in chromatin organization; male meiosis I; and regulation of RNA splicing. Acts upstream of or within with a positive effect on positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; genitourinary system; limb; and maxillary process. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated). PHENOTYPE: Homozygous inactivation of this genes leads to arrest of spermatogenesis and male infertility. [provided by MGI curators] |