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Protein Coding Gene : Brdt bromodomain, testis-specific

Primary Identifier  MGI:1891374 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  114642
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables histone reader activity and lysine-acetylated histone binding activity. Involved in chromatin organization; male meiosis I; and regulation of RNA splicing. Acts upstream of or within with a positive effect on positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; genitourinary system; limb; and maxillary process. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated).
PHENOTYPE: Homozygous inactivation of this genes leads to arrest of spermatogenesis and male infertility. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 7420412D09 gene,
  • MGI:2442307,
  • Brdt,
  • 7420412D09Rik,
  • Brd6,
  • female sterile homeotic-related gene 3,
  • bromodomain, testis-specific,
  • Fsrg3

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For