| Primary Identifier | MGI:104654 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 11921 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in negative regulation of gliogenesis; positive regulation of inner ear receptor cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including generation of neurons; neuroblast migration; and positive regulation of inner ear auditory receptor cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; inner ear; and skin. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human ATOH1 (atonal bHLH transcription factor 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit a decreased cerebellum without folia, and lack cerebellar granule neurons, inner-ear hair cells, D1 interneurons, and goblet, enteroendocrine, and Paneth cells. Mutants fail to breathe properly and die at birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
