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Protein Coding Gene : Lair1 leukocyte-associated Ig-like receptor 1

Primary Identifier  MGI:105492 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  52855
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1).
PHENOTYPE: Mice homozygous for a knock-out allele are healthy and of normal longevity but show increased numbers of splenic B, regulatory T, and dendritic cells, and eosinophilia at a young age. Aging homozygotes display a higher frequency of activated and effector/memory T cells and a decreased IgG1 level. [provided by MGI curators]
  • synonyms:
  • D7Bwg0421e,
  • Lair1,
  • mLair-1,
  • leukocyte-associated Ig-like receptor 1,
  • MGI:2142289,
  • expressed sequence BB115266,
  • 5133400O11Rik,
  • Lair-1,
  • MGD-MRK-33164,
  • DNA segment, Chr 7, Brigham & Women's Genetics 0421 expressed,
  • BB115266,
  • MGI:1918474,
  • RIKEN cDNA 5133400O11 gene

Features --> Cross References

Genome

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0 Exons

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

5 Pathways

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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