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Protein Coding Gene : Dlgap2 DLG associated protein 2

Primary Identifier  MGI:2443181 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  244310
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable molecular adaptor activity and protein domain specific binding activity. Involved in modulation of chemical synaptic transmission. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in cranium and nervous system. Orthologous to human DLGAP2 (DLG associated protein 2).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit novelty-induced hyperactivity, increased aggression, impaired reverse learning, decreased dendritic spine density, synaptopathies, reduced mESPC amplitude and enhanced paired-pulse ratio. [provided by MGI curators]
  • synonyms:
  • DLG associated protein 2,
  • Dlgap2,
  • Sapap2,
  • 6430596N04Rik,
  • RIKEN cDNA 6430596N04 gene,
  • PSD-95/SAP90-binding protein 2,
  • SAP90/PSD-95-associated protein 2,
  • DAP2

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For