| Primary Identifier | MGI:1924574 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 234214 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein domain specific binding activity. Acts upstream of or within Notch signaling pathway; acetylcholine receptor signaling pathway; and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in plasma membrane and synapse. Is expressed in several structures, including brain; cardiovascular system; cranium; foot bone; and foregut. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial postnatal lethality, reduced dendritic complexity, decreased excitatory synaptic transmission in dentate gyrus granule cells, a reduced acoustic startle response, and impaired long-term object recognition memory and contextual fear memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
