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Protein Coding Gene : Sik2 salt inducible kinase 2

Primary Identifier  MGI:2445031 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  235344
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables ion binding activity and protein kinase activity. Involved in several processes, including negative regulation of lipid biosynthetic process; regulation of insulin receptor signaling pathway; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within insulin receptor signaling pathway. Located in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and heart. Orthologous to human SIK2 (salt inducible kinase 2).
PHENOTYPE: Mice heterozygous for a knock-out allele exhibit darkened hair color in an agouti background. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA G630080D20 gene,
  • salt induceable kinase 2,
  • Snf1lk2,
  • SNF1-like kinase 2,
  • salt inducible kinase 2,
  • Sik2,
  • G630080D20Rik

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