Primary Identifier | MGI:1341188 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 18209 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Predicted to act upstream of or within myoblast fusion and regulation of DNA-templated transcription. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; nervous system; and tooth. Orthologous to human NTN3 (netrin 3). PHENOTYPE: Mice homozygous for a null allele are viable and show no detectable developmental or behavioral defects. However, streptozotocin-induced diabetic mice exhibit aberrant spouting of sensory axons into epidermal areas with markedly worse mechanical and cold allodynia. [provided by MGI curators] |