| First Author | Issemann I | Year | 1990 |
| Journal | Nature | Volume | 347 |
| Issue | 6294 | Pages | 645-50 |
| PubMed ID | 2129546 | Mgi Jnum | J:10775 |
| Mgi Id | MGI:59220 | Doi | 10.1038/347645a0 |
| Citation | Issemann I, et al. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators [see comments]. Nature 347(6294):645-50 |
| abstractText | We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man. |
