| First Author | Ghosh S | Year | 1990 |
| Journal | Cell | Volume | 62 |
| Issue | 5 | Pages | 1019-29 |
| PubMed ID | 2203532 | Mgi Jnum | J:25020 |
| Mgi Id | MGI:72736 | Doi | 10.1016/0092-8674(90)90276-k |
| Citation | Ghosh S, et al. (1990) Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell 62(5):1019-29 |
| abstractText | The DNA binding subunit of the transcription factor NF-kappa B, p50, has been cloned. p50 appears to be synthesized as a larger protein that is then processed to its functional size. Sequence analysis reveals remarkable homology for over 300 amino acids at the amino-terminal end to the oncogene v-rel, its cellular homolog c-rel, and the Drosophila maternal effect gene dorsal. This establishes NF-kappa B as a member of the rel family of proteins, all of which display nuclear-cytosolic translocation. Protein sequence from the p65 polypeptide has established that it is not encoded in the same mRNA as p50. However, p65 appears homologous to c-rel, suggesting that c-rel may form heterodimers with p50 and rel may include a homodimerization motif. |
