Primary Identifier | MGI:3525073 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(CAG-WRN*K577M)5025Wcl |
Strain of Origin | C57BL/6 x C3H | Is Recombinase | false |
Is Wild Type | false |
description | This line is representative of three lines made, which include the 4128, 4998 and the 5025 lines. |
molecularNote | The transgene is composed of a full length cDNA encoding human WRN with a mutation that alters lysine 577 to methionine expressed under the control of a cytomegalovirus enhancer and a chicken beta-actin promoter, and was followed by a rabbit beta-globin polyadenylation site. |