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Allele : Gnao1<tm2Lbi> guanine nucleotide binding protein, alpha O; targeted mutation 2, Lutz Birnbaumer
Primary Identifier  MGI:4889046 Allele Type  Targeted
Attribute String  Null/knockout Gene  Gnao1
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<b-m2>
Is Recombinase  false Is Wild Type  false
molecularNote  An IRES-beta galactosidase and PGK-neomycin cassette was inserted in exon 7.1 at the aspartic acid position 262. Isoform Go1-alpha was disrupted while beta galactosidase was placed under the control of the Gnao1 promoter. Absence of the protein product from brain and pancreatic islets was confirmed immunologically.
  • mutations:
  • Insertion
  • synonyms:
  • Go1alpha<->,
  • Go1alpha<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

4 Publication categories





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