| First Author | Marquez-Lona EM | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 417 |
| Issue | 1 | Pages | 514-20 |
| PubMed ID | 22166220 | Mgi Jnum | J:180301 |
| Mgi Id | MGI:5306076 | Doi | 10.1016/j.bbrc.2011.11.152 |
| Citation | Marquez-Lona EM, et al. (2012) Nucleolar stress characterized by downregulation of nucleophosmin: A novel cause of neuronal degeneration. Biochem Biophys Res Commun 417(1):514-20 |
| abstractText | Nucleophosmin (NPM) is a multifunctional nucleolar protein that has been linked with nucleolar stress. In non-neuronal cell lines, NPM may enhance or inhibit the activity of tumor suppressor p53, a major apoptotic protein. The relationship between NPM and p53 in the central nervous system (CNS) remains unknown. Here, we assessed the role of NPM in the CNS using a model of seizure-induced neurodegeneration. We show that NPM overexpression is neuroprotective against kainic acid-induced excitotoxicity, and that downregulation of NPM is pro-apoptotic in a p53-independent manner. These results suggest a key role for NPM in promoting neuronal survival and a novel mechanism of neuronal degeneration triggered by nucleolar stress. |
