Primary Identifier | MGI:2684761 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Malt1 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A floxed neomycin resistance gene was placed in intron 10 and an additional loxP site was placed in intron 12. Transient transfection of correctly targeted ES cells with a plasmid expressing Cre-recombinase eliminated the neomycin gene along with exons 11 and 12. Absence of protein product in resulting homozygous mice was demonstrated by Western blot analysis. |