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Allele : Rest<tm1And> RE1-silencing transcription factor; targeted mutation 1, David J Anderson

Primary Identifier	MGI:3640355	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Rest
Transmission	Germline	Strain of Origin	129S7/SvEvBrd-Hprt1<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance cassette replaced the ATG and the sequence encoding the first four zinc fingers. Western blot failed to detect protein in mutant ES cells.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Rest<deltaN>,
Rest<->,
Rest<->,
Rest<deltaN>

earliestPublication:
Chen ZF, et al. (1998) NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [see comments]. Nat Genet 20(2):136-42

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

6 Publication categories

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