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Allele : Ptpn4<tm1.1Oers> protein tyrosine phosphatase, non-receptor type 4; targeted mutation 1.1, Nicolai S C van Oers

Primary Identifier	MGI:3809671	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Ptpn4
Transmission	Germline	Strain of Origin	129S6/SvEvTac
Is Recombinase	false	Is Wild Type	false

molecularNote

In vivo Cre mediated recombination of Ptpn4^tm1Oers removed exons 21 - 24. RT-PCR confirmed the absence of the full length transcript but detected low levels of a truncated transcript in the thymus, spleen and testes of homozygous mice.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

earliestPublication:
Young JA, et al. (2008) The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions. Mol Immunol 45(14):3756-66

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

4 Publication categories

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