Primary Identifier | MGI:5775152 | Allele Type | Targeted |
Attribute String | Not Specified | Gene | Zbp1 |
Transmission | Germline | Strain of Origin | C57BL/6N |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting construct introduced several nucleotide substitutions (N46A [AAT to GCT] and Y50A [TAC to GCC] in exon 2 and N122A [AAC to GCC] and Y126A [TAT to GCT] in exon 3), that results in the amino acid substitutions of alanine for asparagine and tyrosine at positions 122 and 126 (N122A/Y126A). The final allele lacks a self-deleting neomycin resistance cassette. |