Other
15 Authors
- Nguyen Q,
- Vu R,
- Han W,
- Pearlman E,
- Gutierrez G,
- Kessenbrock K,
- Wu J,
- Shi Y,
- Dragan M,
- Sun P,
- Chen Z,
- Dai X,
- Haensel D,
- Atwood S,
- Greenberg E
| First Author | Sun P | Year | 2021 |
| Journal | J Invest Dermatol | Volume | 141 |
| Issue | 6 | Pages | 1542-1552 |
| PubMed ID | 33333123 | Mgi Jnum | J:320260 |
| Mgi Id | MGI:6823396 | Doi | 10.1016/j.jid.2020.10.025 |
| Citation | Sun P, et al. (2021) OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia. J Invest Dermatol 141(6):1542-1552 |
| abstractText | Psoriasis is a common inflammatory skin disease characterized by aberrant inflammation and epidermal hyperplasia. Molecular mechanisms that regulate psoriasis-like skin inflammation remain to be fully understood. Here, we show that the expression of Ovol1 (encoding ovo-like 1 transcription factor) is upregulated in psoriatic skin, and its deletion results in aggravated psoriasis-like skin symptoms following stimulation with imiquimod. Using bulk and single-cell RNA sequencing, we identify molecular changes in the epidermal, fibroblast, and immune cells of Ovol1-deficient skin that reflect an altered course of epidermal differentiation and enhanced inflammatory responses. Furthermore, we provide evidence for excessive full-length IL-1alpha signaling in the microenvironment of imiquimod-treated Ovol1-deficient skin that functionally contributes to immune cell infiltration and epidermal hyperplasia. Collectively, our study uncovers a protective role for OVOL1 in curtailing psoriasis-like inflammation and the associated skin pathology. |
