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Search results 101 to 193 out of 193 for Mettl14

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:6358350
Age: embryonic day 15.5
Specimen Label: 1f E15.5 Mettl14f/f;Nestin-cre
Detected: false
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6358350
Age: embryonic day 15.5
Specimen Label: 1f E15.5 Mettl14f/+;Nestin-cre
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6358350
Age: embryonic day 17.5
Specimen Label: 1f E17.5 Mettl14f/f
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754425
Stage: TS25
Assay Id: MGI:6358350
Age: embryonic day 17.5
Specimen Label: 1f E17.5 Mettl14f/f;Nestin-cre
Detected: false
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6358350
Age: embryonic day 17.5
Specimen Label: 1f E17.5 Mettl14f/+;Nestin-cre
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6358350
Age: postnatal day 0
Specimen Label: 1f P0 Mettl14f/f
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
     
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:6358350
Age: postnatal day 0
Specimen Label: 1f P0 Mettl14f/f;Nestin-cre
Detected: false
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:6358282
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6358350
Age: postnatal day 0
Specimen Label: 1f P0 Mettl14f/+;Nestin-cre
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Probe: MGI:3085677
Assay Type: RNA in situ
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7516905
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
28792938 | J:249262
First Author: Li HB
Year: 2017
Journal: Nature
Title: m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.
Volume: 548
Issue: 7667
Pages: 338-342
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Publication
35512709 | J:326534
First Author: Raj N
Year: 2022
Journal: Mol Cell
Title: The Mettl3 epitranscriptomic writer amplifies p53 stress responses.
Volume: 82
Issue: 13
Pages: 2370-2384.e10
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Publication
29547716 | J:261823
First Author: Wen J
Year: 2018
Journal: Mol Cell
Title: Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Volume: 69
Issue: 6
Pages: 1028-1038.e6
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Publication
29507755 | J:319950
 
First Author: Yue Y
Year: 2018
Journal: Cell Discov
Title: VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
Volume: 4
Pages: 10
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Publication
27864010 | J:239613
 
First Author: Zhang J
Year: 2017
Journal: Gene
Title: Differentially expressed genes in the testicular tissues of adenylyl cyclase 3 knockout mice.
Volume: 602
Pages: 33-42
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Publication
25569111 | J:219587
First Author: Geula S
Year: 2015
Journal: Science
Title: Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Volume: 347
Issue: 6225
Pages: 1002-6
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Publication
35874829 | J:327184
 
First Author: Xiao Z
Year: 2022
Journal: Front Cell Dev Biol
Title: The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.
Volume: 10
Pages: 882994
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Publication
32404350 | J:296911
First Author: Wang Y
Year: 2020
Journal: Diabetes
Title: m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Volume: 69
Issue: 8
Pages: 1708-1722
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Publication
29879109 | J:263687
First Author: Wang CX
Year: 2018
Journal: PLoS Biol
Title: METTL3-mediated m6A modification is required for cerebellar development.
Volume: 16
Issue: 6
Pages: e2004880
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Publication
37269288 | J:337931
First Author: Li L
Year: 2023
Journal: Cell Rep
Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
Volume: 42
Issue: 6
Pages: 112596
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 441
Description: Interaction with METTL14
Type: site
End: 441
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UniProt Feature
UniProt Feature
Begin: 438
Description: Interaction with METTL14
Type: site
End: 438
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HT Experiment
GSE206013 | Single-cell RNA-sequencing of Mettl14 conditional knock-out retinas and matched controls
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE162906 | Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
33903120 | J:307932
First Author: Du L
Year: 2021
Journal: Cancer Res
Title: USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Volume: 81
Issue: 14
Pages: 3822-3834
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Publication
27373337 | -
First Author: Wang P
Year: 2016
Journal: Mol Cell
Title: Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Volume: 63
Issue: 2
Pages: 306-317
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Allele
Mettl14<em1Smoc> | MGI:7291040
Name: methyltransferase 14, N6-adenosine-methyltransferase subunit; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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HT Experiment
GSE171422 | m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:6355015 | C57BL/6J-Mettl14<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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HT Experiment
GSE171421 | m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [bulkRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:0036396 | RNA N6-methyladenosine methyltransferase complex
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Publication
34142067 | J:312216
First Author: Zhou P
Year: 2021
Journal: iScience
Title: Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1.
Volume: 24
Issue: 6
Pages: 102645
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Publication
38349790 | J:346156
First Author: Foucault L
Year: 2024
Journal: Cell Rep
Title: Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors.
Volume: 43
Issue: 2
Pages: 113734
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Protein Coding Gene
MGI:1914552 | Zc3h13
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
G5E922
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: true
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Protein Domain
IPR025848 | MT-A70
Type: Family
Description: METTL3 and METTL14 (methyltransferase-like) form a methyltransferase complex that methylates adenosine residues at the N6 position of some RNAs, forming N6-methyladenosine (m6A). METTL3, also known as MT-A70, is the catalytic subunit of this complex, and accepts S-adenosyl methionine, a donor for methylation []. m6A, which is present at internal sites of some mRNAs, affects different aspects of mRNA metabolism such as half-life, splicing, and translation [, , , , ].Methyltransferases (EC [intenz:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.
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Protein Coding Gene
MGI:2144842 | Cbll1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926395 | Wtap
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913435 | Virma
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31751468 | J:286650
First Author: Cao Y
Year: 2020
Journal: Hum Mol Genet
Title: Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice.
Volume: 29
Issue: 5
Pages: 727-735
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Publication
30867593 | J:274814
First Author: Huang H
Year: 2019
Journal: Nature
Title: Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.
Volume: 567
Issue: 7748
Pages: 414-419
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Publication
38182816 | J:345634
First Author: Xu J
Year: 2024
Journal: EMBO Rep
Title: DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
Volume: 25
Issue: 2
Pages: 770-795
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Protein Coding Gene
MGI:1924031 | Mettl4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923598 | Rbm15b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2443205 | Rbm15
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24284625 | -
First Author: Wang X
Year: 2014
Journal: Nature
Title: N6-methyladenosine-dependent regulation of messenger RNA stability.
Volume: 505
Issue: 7481
Pages: 117-20
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Publication
26751643 | -
First Author: Choi J
Year: 2016
Journal: Nat Struct Mol Biol
Title: N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics.
Volume: 23
Issue: 2
Pages: 110-5
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Publication
26593424 | -
First Author: Meyer KD
Year: 2015
Journal: Cell
Title: 5' UTR m(6)A Promotes Cap-Independent Translation.
Volume: 163
Issue: 4
Pages: 999-1010
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Publication
26046440 | -
First Author: Wang X
Year: 2015
Journal: Cell
Title: N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Volume: 161
Issue: 6
Pages: 1388-99
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Publication
25799998 | J:220463
First Author: Alarcón CR
Year: 2015
Journal: Nature
Title: N6-methyladenosine marks primary microRNAs for processing.
Volume: 519
Issue: 7544
Pages: 482-5
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Protein
Q8C3P7
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q3U6J4
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: true
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Protein
A0A0R4J041
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein Coding Gene
MGI:1927165 | Mettl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7897657 | -
First Author: Schluckebier G
Year: 1995
Journal: J Mol Biol
Title: Universal catalytic domain structure of AdoMet-dependent methyltransferases.
Volume: 247
Issue: 1
Pages: 16-20
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Publication
16225687 | -
 
First Author: Kozbial PZ
Year: 2005
Journal: BMC Struct Biol
Title: Natural history of S-adenosylmethionine-binding proteins.
Volume: 5
Pages: 19
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Publication
21858014 | -
First Author: Wlodarski T
Year: 2011
Journal: PLoS One
Title: Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.
Volume: 6
Issue: 8
Pages: e23168
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Publication
12826405 | -
First Author: Schubert HL
Year: 2003
Journal: Trends Biochem Sci
Title: Many paths to methyltransfer: a chronicle of convergence.
Volume: 28
Issue: 6
Pages: 329-35
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