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Search results 601 to 700 out of 725 for Rptor

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Type Details Score
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap OST397611, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap E090A07, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap E090C07, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap TEA051, BayGenomics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0047d10, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap CSD145, BayGenomics
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.1, Mark A Magnuson
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0087g01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCJ0153b01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1, Mark A Magnuson
Allele Type: Targeted
Attribute String: Conditional ready, Hypomorph, Reporter
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap CSD163, BayGenomics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap E122D06, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCJ0020c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.1, Kun-Liang Guan
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0273c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; gene trap RRR347, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap OST48752, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE00102e04, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.1, Michael N Hall
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap D113B11, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0095c04, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap CSD072, BayGenomics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap XH216, BayGenomics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap A036C02, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0195c09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 8, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.2, Mark A Magnuson
Allele Type: Targeted
Attribute String: Null/knockout
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap AZ0553, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap XN573, BayGenomics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCJ0092a03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap CSD158, BayGenomics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap OST406268, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE00130e05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap D037G12, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap E090B07, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap S1-7C1, Philippe Soriano
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0258h12, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.3, Mark A Magnuson
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap E090C08, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE00112h12, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0196a06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Publication
First Author: Signer RA
Year: 2014
Journal: Nature
Title: Haematopoietic stem cells require a highly regulated protein synthesis rate.
Volume: 509
Issue: 7498
Pages: 49-54
Publication
First Author: Lee D
Year: 2014
Journal: Stem Cell Reports
Title: Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.
Volume: 3
Issue: 5
Pages: 832-40
Publication  
First Author: Byles V
Year: 2013
Journal: Nat Commun
Title: The TSC-mTOR pathway regulates macrophage polarization.
Volume: 4
Pages: 2834
Publication    
First Author: Porter SN
Year: 2016
Journal: Elife
Title: Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.
Volume: 5
Publication
First Author: Sato R
Year: 2018
Journal: Nat Immunol
Title: Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.
Volume: 19
Issue: 10
Pages: 1071-1082
Publication
First Author: Parker SJ
Year: 2018
Journal: Am J Physiol Heart Circ Physiol
Title: Proteomics reveals Rictor as a noncanonical TGF-β signaling target during aneurysm progression in Marfan mice.
Volume: 315
Issue: 5
Pages: H1112-H1126
Publication
First Author: Hagan GN
Year: 2008
Journal: Mol Cell Biol
Title: A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Volume: 28
Issue: 13
Pages: 4215-26
Publication
First Author: Jung SM
Year: 2019
Journal: Mol Cell
Title: Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Volume: 75
Issue: 4
Pages: 807-822.e8
Publication
First Author: Charbonnier LM
Year: 2015
Journal: Nat Immunol
Title: Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.
Volume: 16
Issue: 11
Pages: 1162-73
Publication
First Author: Martinez Calejman C
Year: 2020
Journal: Nat Commun
Title: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
Volume: 11
Issue: 1
Pages: 575
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication  
First Author: Raynor JL
Year: 2020
Journal: J Exp Med
Title: Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.
Volume: 217
Issue: 6
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST14743F3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST14888F4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST15070E11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST10543A11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST14219G9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST10543A6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST12128E12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: congenic, mutant strain, targeted mutation
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: B6.Cg-Rictor Tg(Fabp4-cre)1Rev
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Liu C
Year: 2021
Journal: Sci Adv
Title: Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Volume: 7
Issue: 41
Pages: eabg6262
Publication
First Author: McGuire VA
Year: 2013
Journal: Mol Cell Biol
Title: Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.
Volume: 33
Issue: 21
Pages: 4152-65
Publication
First Author: Hresko RC
Year: 2005
Journal: J Biol Chem
Title: mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Volume: 280
Issue: 49
Pages: 40406-16
Publication
First Author: Jacinto E
Year: 2006
Journal: Cell
Title: SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Volume: 127
Issue: 1
Pages: 125-37
Publication
First Author: Tao R
Year: 2015
Journal: Diabetes
Title: Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Volume: 64
Issue: 4
Pages: 1211-23
Publication
First Author: Julien LA
Year: 2010
Journal: Mol Cell Biol
Title: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Volume: 30
Issue: 4
Pages: 908-21
Publication
First Author: Zhang C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
Volume: 109
Issue: 5
Pages: 1667-72
Publication
First Author: Gao D
Year: 2010
Journal: Mol Cell
Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Volume: 39
Issue: 5
Pages: 797-808
Publication
First Author: Ou YH
Year: 2011
Journal: Mol Cell
Title: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Volume: 41
Issue: 4
Pages: 458-70
Publication
First Author: Betz C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology.
Volume: 110
Issue: 31
Pages: 12526-34
Publication
First Author: Akgül S
Year: 2018
Journal: Cell Rep
Title: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Volume: 24
Issue: 2
Pages: 463-478.e5
Publication
First Author: Zhu Y
Year: 2019
Journal: Cell Death Differ
Title: Superhero Rictor promotes cellular differentiation of mouse embryonic stem cells.
Volume: 26
Issue: 5
Pages: 958-968
Publication
First Author: Inomata M
Year: 2021
Journal: Exp Cell Res
Title: Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis.
Volume: 398
Issue: 2
Pages: 112416
Publication  
First Author: Chen WY
Year: 2017
Journal: Sci Rep
Title: Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation.
Volume: 7
Pages: 41159
Publication
First Author: Zhang Z
Year: 2012
Journal: Mol Cell Biochem
Title: mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.
Volume: 361
Issue: 1-2
Pages: 249-57
Publication
First Author: Shiota C
Year: 2006
Journal: Dev Cell
Title: Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.
Volume: 11
Issue: 4
Pages: 583-9
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Strain
Attribute String: congenic, targeted mutation, transgenic
Genotype
Symbol: Rictor/Rictor Tg(ACTA1-cre)1Mll/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Tg(Fabp4-cre)1Rev/?
Background: B6.Cg-Rictor Tg(Fabp4-cre)1Rev
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Tg(Ins2-cre)25Mgn/?
Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Rictor Tg(Mx1-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Zhang C
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.
Volume: 307
Issue: 3
Pages: E305-15