Primary Identifier | MGI:6266856 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Als2 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A PGK-neomycin selection cassette replaced most of exon 4 and a portion of intron 4, producing a translation product of 171 amino acids followed by 3 unique residues and a premature stop codon at amino acid 175. Immunoblot of brain lysates indicates no detectable full-length protein or short forms of the protein in homozygotes. |